resumo
Fisetin is a natural antioxidant with a wide range of nutraceutical properties, including antidiabetic, neuroprotecting, and suppression or prevention of tumors. The present work describes the preparation of a water-soluble, solid inclusion compound of fisetin with gamma-cyclodextrin (gamma-CD), a cyclic oligosaccharide approved for human consumption. A detailed physicochemical analysis of the product is carried out using elemental analysis, powder X-ray diffraction (PXRD), Raman, infrared and C-13{H-1} CP-MAS NMR spectroscopies, and thermal analysis (TGA) to verify fisetin inclusion and to present a hypothetical structural arrangement for the host-guest units. The antioxidant activity of the gamma-CD fisetin inclusion compound is evaluated by the DPPH assay.
palavras-chave
BETA-CYCLODEXTRIN; IMPROVES BIOAVAILABILITY; IN-VITRO; FLAVONOIDS; SUPPLEMENTATION; COMPLEXES; MICE; FORMULATION; CRYSTAL
categoria
Chemistry
autores
Pais, JM; Barroca, MJ; Marques, MPM; Paz, FAA; Braga, SS
nossos autores
Filipe Alexandre Almeida Paz
Investigador Principal
Susana Isabel Fonseca de Almeida Santos Braga
Investigadoragradecimentos
The supply of gamma-CD (pharmaceutical grade Cavamax W8, manufactured by Wacker-Chemie) by Ashland Specialty Ingredients (Dusseldorf, Germany) is gracefully acknowledged. We are also grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal), European Union, QREN, European Fund for Regional Development (FEDER), through the programme COMPETE, for general funding to the QOPNA research unit (project PEst C-QUI/UI0062/2013; FCOMP-01-0124-FEDER-037296), to UID/MULTI/00070/2013 and to the R&D Project ReNATURE (C2020-01-0145-FEDER-000007).