Amino acid/water interactions study: a new amino acid scale
authors Madeira, PP; Bessa, A; Alvares-Ribeiro, L; Aires-Barros, MR; Rodrigues, AE; Uversky, VN; Zaslavsky, BY
nationality International
journal JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
author keywords biological activity; protein structure; amino acids; descriptors; aqueous two-phase partitioning
keywords SOLVATOCHROMIC COMPARISON METHOD; AQUEOUS 2-PHASE SYSTEMS; PARTITION-COEFFICIENTS; DISORDERED PROTEIN; INTRINSIC DISORDER; SIDE-CHAINS; PI-STAR; BETA; DESCRIPTORS; THRESHOLDS
abstract Partition ratios of 8 free l-amino acids (Gln, Glu, His, Lys, Met, Ser, Thr, and Tyr) were measured in 10 different polymer/polymer aqueous two-phase systems containing 0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4. The solute-specific coefficients representing the solute dipole/dipole, hydrogen-bonding and electrostatic interactions with the aqueous environment of the amino acids were determined by multiple linear regression analysis using a modified linear solvation energy relationship. The solute-specific coefficients determined in this study together with the solute-specific coefficients reported previously for amino acids with non-polar side-chains where used in a Quantitative Structure/Property Relationship analysis. It is shown that linear combinations of these solute-specific coefficients are correlated well with various physicochemical, structural, and biological properties of amino acids.
publisher TAYLOR & FRANCIS INC
issn 0739-1102
year published 2014
volume 32
issue 6
beginning page 959
ending page 968
digital object identifier (doi) 10.1080/07391102.2013.800994
web of science category Biochemistry & Molecular Biology; Biophysics
subject category Biochemistry & Molecular Biology; Biophysics
unique article identifier WOS:000331524500009
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