PET/CT Imaging with an F-18-Labeled Galactodendritic Unit in a Galectin-1-Overexpressing Orthotopic Bladder Cancer Model
authors Pereira, PMR; Roberts, S; Figueira, F; Tome, JPC; Reiner, T; Lewis, JS
nationality International
journal JOURNAL OF NUCLEAR MEDICINE
author keywords dendritic carbohydrate; PET/CT imaging; bladder cancer; galectins; F-18-radiochemistry
keywords PHOTODYNAMIC THERAPY; GALECTIN-3
abstract Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with F-18 (F-18-labeled galactodendritic unit 4) and examined its potential in imaging urothelial malignancies. Methods: The F-18-labeled first-generation galactodendritic unit 4 was obtained from its tosylate precursor. We conducted in vivo studies in a galectin-expressing UMUC3 orthotopic BCa model to determine the ability of F-18-labeled galactodendritic unit 4 to image BCa. Results: Intravesical administration of F-18-labeled galactodendritic unit 4 allowed specific accumulation of the carbohydrate radiotracer in galectin-1-overexpressing UMUC3 orthotopic tumors when imaged with PET. The F-18-labeled galactodendritic unit 4 was not found to accumulate in nontumor murine bladders. Conclusion: The F-18-labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1-overexpressing bladder tumors.
publisher SOC NUCLEAR MEDICINE INC
issn 0161-5505
isbn 1535-5667
year published 2020
volume 61
issue 9
beginning page 1369
ending page 1375
digital object identifier (doi) 10.2967/jnumed.119.236430
web of science category Radiology, Nuclear Medicine & Medical Imaging
subject category Radiology, Nuclear Medicine & Medical Imaging
unique article identifier WOS:000568832100026
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 7.887
5 year journal impact factor 6.782
category normalized journal impact factor percentile 97.368
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg