authors |
Pereira, PMR; Roberts, S; Figueira, F; Tome, JPC; Reiner, T; Lewis, JS |
nationality |
International |
journal |
JOURNAL OF NUCLEAR MEDICINE |
author keywords |
dendritic carbohydrate; PET/CT imaging; bladder cancer; galectins; F-18-radiochemistry |
keywords |
PHOTODYNAMIC THERAPY; GALECTIN-3 |
abstract |
Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with F-18 (F-18-labeled galactodendritic unit 4) and examined its potential in imaging urothelial malignancies. Methods: The F-18-labeled first-generation galactodendritic unit 4 was obtained from its tosylate precursor. We conducted in vivo studies in a galectin-expressing UMUC3 orthotopic BCa model to determine the ability of F-18-labeled galactodendritic unit 4 to image BCa. Results: Intravesical administration of F-18-labeled galactodendritic unit 4 allowed specific accumulation of the carbohydrate radiotracer in galectin-1-overexpressing UMUC3 orthotopic tumors when imaged with PET. The F-18-labeled galactodendritic unit 4 was not found to accumulate in nontumor murine bladders. Conclusion: The F-18-labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1-overexpressing bladder tumors. |
publisher |
SOC NUCLEAR MEDICINE INC |
issn |
0161-5505 |
isbn |
1535-5667 |
year published |
2020 |
volume |
61 |
issue |
9 |
beginning page |
1369 |
ending page |
1375 |
digital object identifier (doi) |
10.2967/jnumed.119.236430 |
web of science category |
Radiology, Nuclear Medicine & Medical Imaging |
subject category |
Radiology, Nuclear Medicine & Medical Imaging |
unique article identifier |
WOS:000568832100026
|