|
authors |
Pereira, PMR; Roberts, S; Figueira, F; Tome, JPC; Reiner, T; Lewis, JS |
|
nationality |
International |
|
journal |
JOURNAL OF NUCLEAR MEDICINE |
|
author keywords |
dendritic carbohydrate; PET/CT imaging; bladder cancer; galectins; F-18-radiochemistry |
|
keywords |
PHOTODYNAMIC THERAPY; GALECTIN-3 |
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abstract |
Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with F-18 (F-18-labeled galactodendritic unit 4) and examined its potential in imaging urothelial malignancies. Methods: The F-18-labeled first-generation galactodendritic unit 4 was obtained from its tosylate precursor. We conducted in vivo studies in a galectin-expressing UMUC3 orthotopic BCa model to determine the ability of F-18-labeled galactodendritic unit 4 to image BCa. Results: Intravesical administration of F-18-labeled galactodendritic unit 4 allowed specific accumulation of the carbohydrate radiotracer in galectin-1-overexpressing UMUC3 orthotopic tumors when imaged with PET. The F-18-labeled galactodendritic unit 4 was not found to accumulate in nontumor murine bladders. Conclusion: The F-18-labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1-overexpressing bladder tumors. |
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publisher |
SOC NUCLEAR MEDICINE INC |
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issn |
0161-5505 |
|
isbn |
1535-5667 |
|
year published |
2020 |
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volume |
61 |
|
issue |
9 |
|
beginning page |
1369 |
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ending page |
1375 |
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digital object identifier (doi) |
10.2967/jnumed.119.236430 |
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web of science category |
Radiology, Nuclear Medicine & Medical Imaging |
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subject category |
Radiology, Nuclear Medicine & Medical Imaging |
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unique article identifier |
WOS:000568832100026
|
