authors |
Lan, HB; Nunes, C; Lopes, GR; Wang, K; Zhao, L; Coimbra, MA; Hu, ZY |
nationality |
International |
journal |
CARBOHYDRATE POLYMERS |
author keywords |
Longan polysaccharides; Glucan; Immunomodulatory activity; Linkage analysis; Cytokines |
keywords |
IMMUNOSTIMULATORY ACTIVITY; POLYSACCHARIDES; ACTIVATION; ROOT |
abstract |
Longan (Dimocarpus longan Lour.) is a seasonal tropical fruit used by Chinese medicine in both fresh and dried pulp forms. Their polysaccharides have been reported to have biological activity. However, their composition and immune activity have not yet been disclosed. To fulfil this aim, hot water-soluble polysaccharides of fresh and dried longan pulp were fractionated according to their molecular weight by ultrafiltration (10, 50, 100 kDa cut off). The main polysaccharides recovered were 1,6-linked glucans branched at O-3 (4-8%), O-2 (1%), O-2,4 (0.1%), and O-3,4 (0.1%). The drying process promotes the solubility of the polysaccharides. These glucans from fresh and dried longan pulp have immunomodulatory activity, shown by in vitro phagocytosis, NO, TNF-alpha, and IL6 macrophages production assays. They showed also to inhibit the inflammatory response induced by LPS. The immunological activity of these glucans seems to have different responses dependent on their molecular weight, related to the immune regulatory pathways. |
publisher |
ELSEVIER SCI LTD |
issn |
0144-8617 |
isbn |
1879-1344 |
year published |
2021 |
volume |
266 |
digital object identifier (doi) |
10.1016/j.carbpol.2021.118106 |
web of science category |
10 |
subject category |
Chemistry, Applied; Chemistry, Organic; Polymer Science |
unique article identifier |
WOS:000655699400006
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ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
7.182 |
5 year journal impact factor |
6.89 |
category normalized journal impact factor percentile |
96.638 |
dimensions (citation analysis):
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altmetrics (social interaction):
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