In vitro immunomodulatory activity of water-soluble glucans from fresh and dried Longan (Dimocarpus longan Lour.)
authors Lan, HB; Nunes, C; Lopes, GR; Wang, K; Zhao, L; Coimbra, MA; Hu, ZY
nationality International
journal CARBOHYDRATE POLYMERS
author keywords Longan polysaccharides; Glucan; Immunomodulatory activity; Linkage analysis; Cytokines
keywords IMMUNOSTIMULATORY ACTIVITY; POLYSACCHARIDES; ACTIVATION; ROOT
abstract Longan (Dimocarpus longan Lour.) is a seasonal tropical fruit used by Chinese medicine in both fresh and dried pulp forms. Their polysaccharides have been reported to have biological activity. However, their composition and immune activity have not yet been disclosed. To fulfil this aim, hot water-soluble polysaccharides of fresh and dried longan pulp were fractionated according to their molecular weight by ultrafiltration (10, 50, 100 kDa cut off). The main polysaccharides recovered were 1,6-linked glucans branched at O-3 (4-8%), O-2 (1%), O-2,4 (0.1%), and O-3,4 (0.1%). The drying process promotes the solubility of the polysaccharides. These glucans from fresh and dried longan pulp have immunomodulatory activity, shown by in vitro phagocytosis, NO, TNF-alpha, and IL6 macrophages production assays. They showed also to inhibit the inflammatory response induced by LPS. The immunological activity of these glucans seems to have different responses dependent on their molecular weight, related to the immune regulatory pathways.
publisher ELSEVIER SCI LTD
issn 0144-8617
isbn 1879-1344
year published 2021
volume 266
digital object identifier (doi) 10.1016/j.carbpol.2021.118106
web of science category 10
subject category Chemistry, Applied; Chemistry, Organic; Polymer Science
unique article identifier WOS:000655699400006
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journal analysis (jcr 2019):
journal impact factor 7.182
5 year journal impact factor 6.89
category normalized journal impact factor percentile 96.638
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