A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins
authors Marques, J; Santos, TM; Marques, MP; Braga, SS
nationality International
journal DALTON TRANSACTIONS
keywords DNA-BINDING PROPERTIES; AMINO-ACID COMPLEXES; C-13 CHEMICAL-SHIFTS; BETA-CYCLODEXTRIN; PHARMACEUTICAL APPLICATIONS; INCLUSION COMPLEXES; ANTICANCER ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; PRECURSORS
abstract The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HP beta CD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1: 1 host: guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.
publisher ROYAL SOC CHEMISTRY
issn 1477-9226
year published 2009
issue 44
beginning page 9812
ending page 9819
digital object identifier (doi) 10.1039/b915839a
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000271432600020
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