Tunable transmembrane chloride transport by bis-indolylureas

resumo

A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayers.

palavras-chave

AMBER FORCE-FIELD; ORGANIC-SOLVENTS; ANION RECEPTORS; LIPID-BILAYERS; PHOSPHOLIPID-BILAYERS; BINDING-PROPERTIES; CYSTIC-FIBROSIS; GELATORS; CHANNEL; PRODIGIOSINS

categoria

Chemistry

autores

Haynes, CJE; Moore, SJ; Hiscock, JR; Marques, I; Costa, PJ; Felix, V; Gale, PA

nossos autores

agradecimentos

We thank the EPSRC for studentships (SJM and CJEH) and a PhD Plus award (JRH). In addition we thank the EPSRC for access for the crystallographic facilities at the University of Southampton.66 The computational studies were funded by the FEDER through the Operational Program Competitiveness Factors - COMPETE and National Funds through FCT - Fundacao para a Ciencia e a Tecnologia under project PTDC/QUI-QUI/101022/2008. P.J.C. thanks FCT for the postdoctoral grant SFRH/BPD/27082/2006.

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