Ongoing Supervisions
Projects
Bioengenharia de materiais vivos compostos por células imunes para imunoterapia do cancro do pâncreas (ALIVE)
CoordinatorFundação para a Ciência e a Tecnologia
Bioengenharia de modelos ósseos biomiméticos para o desenvolvimento de terapias anti-tumorais e regenerativas (ÉLPIS)
PartnerOther National
Metastasis Exploration in the Bone Microenvironment - Breast Cancer Edition (METABONE)
PartnerFundação para a Ciência e a Tecnologia
Supramolecular design of multitactic 3D polymeric biomaterials for spinal cord repair (SUPRANEURO 2)
PartnerFundação para a Ciência e a Tecnologia
Spinal cord injury (SCI) represents one of the leading causes of disability worldwide , being characterized by a permanent loss of motor function and sensory perception owing to the complex pathophysiology and inability of the central nervous system (CNS) to self-regenerate. Currently, the most common therapeutic approaches involve the systemic ...Sustainable 4D hydrogels functionalised with plant-based nanoparticles for bone regeneration in cancer patients (GreenNanoBone)
PartnerEuropean Comission
Biocompatible 4D materials for bone regeneration in MRONJ patients Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severe side effect of bone-targeting agents (BTAs) such as bisphosphonates, prescribed to breast cancer survivors to lower the risk of secondary bone cancer. MRONJ can cause progressive jawbone destruction, leading...Unprecedented photolithographic structuring of novel light-sensitive poly(amino acid) materials- a paradigm shift in delivering biocompatible devices (POLINA)
Local CoordinatorEuropean Comission
Photolitography, which produces geometrical structures through light-induced polymerisation of monomers with high accuracy, precision and spatial resolution, was a key innovation enabler in the drive for high-performance miniature electronics, which had an unprecedented impact on every aspect of our modern life. Geometrically well-defined micros...3D cells colonization in marine-derived hydrogels through controlled micro-channels patterning for bone repair (PROMENADE)
PartnerFundação para a Ciência e a Tecnologia
Maritime Domain Awareness is the combination of activities, events and threats in the maritime environment that could have impact on marine activities and EU territory. During the past decades, advances in Information and Communication Technologies have provided better means to monitor and analyse vessel activity. Today private and public source...Advancing the Regenerative and Translational Potential of Cellular Fibers (CellFi)
PartnerFundação para a Ciência e a Tecnologia
Mesenchymal Stem Cells Scaffold-free Cellular Fibers RegenerationDevelopment of 4D wireless thermometry to target tumor ablation (PTDC/NAN-MAT/3901/2020)
PartnerFundação para a Ciência e a Tecnologia
Thermography Magnetic Nanoparticles Induced Hyperthermia BioprintingDispositivos Supramoleculares Auto-Regulados baseados na Complementaridade dos Pares de Base do ADN: Uma Tecnologia Biomimética e com Reconheciemnto Molecular para Isolar Células Específicas para Aplicações Biomédicas (SUPRASORT)
PartnerFundação para a Ciência e a Tecnologia
Hydralazine: Testing an off-label effect in Castration-Resistant Prostate Cancer (HyTherCaP)
PartnerFundação para a Ciência e a Tecnologia
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies worldwide and a leading cause of cancer-related deaths among men. In Portugal, it is the most incident cancer and the 3rd cause of death (1, 2). Although most of PCa are clinically indolent, a variable proportion of patients develop castration-resistant PCa (CRPC), an aggre...Integrated photonic neuronal probes towards neuromorphic computing (PHEASANT)
PartnerFundação para a Ciência e a Tecnologia
Optical methods have been widely used for stimulation and functional imaging of neural circuits, namely, optogenetics which is a powerful tool for selective excitation or inhibition of specific cell types using light of different wavelengths desirable to stimulate or inhibit a subset of neurons that express the same light-sensitive proteins. The...Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)
PartnerFundação para a Ciência e a Tecnologia
Publications
Hydrogel 3D in vitro tumor models for screening cell aggregation mediated drug response
Monteiro, MV; Gaspar, VM; Ferreira, LP; Mano, JF
2020, BIOMATERIALS SCIENCE, 8, 7, 1855-1864.
ISBN:
2047-4849
>
Mechanochemical Patternable ECM-Mimetic Hydrogels for Programmed Cell Orientation
Lavrador, P; Gaspar, VM; Mano, JF
2020, ADVANCED HEALTHCARE MATERIALS, 9, 10.
ISBN:
2192-2659
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Repurposing Old Drugs into New Epigenetic Inhibitors: Promising Candidates for Cancer Treatment?
Moreira-Silva, F; Camilo, V; Gaspar, V; Mano, JE; Henrique, R; Jeronimo, C
2020, PHARMACEUTICS, 12, 5.
ISBN:
1999-4923
>
Responsive laminarin-boronic acid self-healing hydrogels for biomedical applications
Amaral, AJR; Gaspar, VM; Mano, JF
2020, POLYMER JOURNAL, 52, 8, 997-1006.
ISBN:
1349-0540
>
Self-Assembled Bioactive Colloidal Gels as Injectable Multiparticle Shedding Platforms
Freitas, B; Lavrador, P; Almeida, RJ; Gaspar, VM; Mano, JF
2020, ACS APPLIED MATERIALS & INTERFACES, 12, 28, 31282-31291.
ISBN:
1944-8252
>
Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models
Ferreira, LP; Gaspar, VM; Mano, JF
2020, TRENDS IN BIOTECHNOLOGY, 38, 12, 1397-1414.
ISBN:
1879-3096
>
Differential Modulation of the Phospholipidome of Proinflammatory Human Macrophages by the Flavonoids Quercetin, Naringin and Naringenin
Conde, TA; Mendes, L; Gaspar, VM; Mano, JF; Melo, T; Domingues, MR; Duarte, IF
2020, MOLECULES, 25, 15.
ISBN:
1420-3049
>
In-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening
Antunes, J; Gaspar, VM; Ferreira, L; Monteiro, M; Henrique, R; Jeronimo, C; Mano, JF
2019, ACTA BIOMATERIALIA, 94, 392-409.
ISBN:
1878-7568
>
Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways
Mendes, LF; Gaspar, VM; Onde, TAC; Mano, JF; Duarte, IF
2019, SCIENTIFIC REPORTS, 9.
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Temperature-responsive nanomagnetic logic gates for cellular hyperthermia
Silva, RO; Pereira, RA; Silva, FM; Gaspar, VM; Ibarra, A; Millan, A; Sousa, FL; Mano, JF; Silva, NJO
2019, MATERIALS HORIZONS, 6, 3, 524-530.
ISBN:
2051-6355
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