Maria Helena Figueira Vaz Fernandes

Maria Helena Fernandes is Associate Professor at the Department of Materials and Ceramic Engineering, University of Aveiro (UA) and member of the Associate Laboratory CICECO Aveiro Institute of Materials - Center for Research in Ceramics and Composite Materials, University of Aveiro.

Education: PhD in Materials Science and Engineering, University of Aveiro (1988).Graduation in Chemical Engineering, FEUP, Faculty of Engineering, University Porto (1978)

Academic Responsibilities: Head of Department of Ceramics and Glass Engineering, UA, for 2 years, Coordinator of the Department Scientific Council (2 years), Director of the Materials Engineering Course (2 years) and Director of the Masters on Biomedical Materials and Devices (2 years).

General:

Biomaterials, bioceramics, bioglasses, glasses, glass-ceramics and glass reinforced composites for biomedical applications.

 Transport phenomena and technological processes

Current research interests:

Novel glass compositions for bone regeneration strategies. Glass-containing composites, polymer-nanoparticles composites for regenerative medicine. Films and 3D structures for tissue engineering. Drug loading and delivery. Piezoelectric platforms for tissue regeneration

Scientific Record:

Participant in more than 25 projects, national and international, either as project leader or as collaborator and in several international scientific networks. 

Participant in several industrial valorization projects, with national and European funding.

Supervisor/co-supervisor of 12 PhD thesis (4 running), 50 Master dissertations in national institutions or integrated in scientific collaborations with foreign institutions, and sponsor of 5 post doc scholars.

Author of 1 book, 4 book chapters, co-author of 7 national patents, 1 international patent, 2 registered marks, more than 150 papers in journals and Proceedings and about 100 participations in oral and poster presentations or as invited speaker.

Recent Editorial activities: Member of Editorial Board  of Journal of Biomaterials Applications, 2016; Guest Editor of Revista da SPM Special Issue Biomaterials, 2014

Evaluator of projects AdI, POCTI and POSI programs (Portuguese Science Ministry) and National Science Centre (Poland)

Referee of papers in more than 25 different SCI journals (IF 1-10)

Chair and Co-chair of several national and international meetings.

Jury member or examiner of about 50 MSc exams and 26 PhD defenses.

Member of the Portuguese Ceramics and Glass Society and of the Portuguese Materials Society with the coordination of the Biomaterials Division.

On-going projects with posdoc research fellows:

Nathalie Barroca, José Carlos Almeida, Erika Davim, Marisa Costa

PhD students:

Ana Margarida Silva, Liliana Pires (co-supervision), Tiago Marques Filipe Araújo (co-supervision),

MsC students:

Andreia Leal, Adriana Magueta, Viviana Gomes (Master in Biomedical Materials and Devices), Ana Fernandes (Master in Biology, co-supervision)

Staff from the University of Aveiro involved in running scientific projects:

Maria Elizabete Costa, Paula Vilarinho, Isabel Salvado, Ana Maria Senos, Augusto Lopes (Department of Materials and Ceramic Engineering), Lourdes Pereira (Biology Department), Martinho Oliveira (School of Design, Management and Production Technology)  Odete Cruz e Silva (Department of Medical Sciences)

Staff from other institutions:

In Portugal:

Helena Raposo Fernandes (Faculty of Dental Medicine, University of Porto) Ana Colette (ICBAS, Institute of Biomedical Sciences Abel Salazar, University of Porto), Mª Ascensão Lopes (Faculty of Engeneering, University of Porto)

In Spain:

Julia Serra (Applied Physics Department, University of Vigo, Spain), Julio Suay (Departamento de Sistemas Industriales y Diseño, Escuela Superior de Tecnología y Ciencias Experimentales, University  Jaime I, Castellón (Spain)

In UK:

Jonathan Knowles (Eastman Dental Institute, Faculty of Medical Sciences, University College London, UK

In Germany:

Christian Russel (Otto Schott Institute, University of Jena, Germany), Aldo Boccaccini (Department for Materials Science, Friedrich-Alexander-University Erlangen-Nuremberg, Germany)

In Bulgaria:

Ivanova Yordanka and Lachezar Radev (Department of Silicates Technology, University of Sofia, Bulgária)

In Ireland:

Brian Rodriguez (University College Dublin, Conway Institute of Biomolecular and Biomedical Research)

In Brazil:

Cecília Zavaglia (Universidade Estadual de Campinas, Brasil), Claudinei Santos (Escola de Engenharia de Lorena, Universidade de São Paulo, Brasil), Necesio Costa (Universidade Federal de Itajubá).Silvia Denofre Universidade Estadual do Oeste do Paraná (Brasil)

In India:

Naheed Ahmad (Department of Botany, Patna University, India.

Over 15 different courses (tutorials and practical classes) on specialized topics (glasses, biomaterials) and on basic engineering (transfer phenomena, technological processes) at the University of Aveiro and in other universities. Supervision of research projects and training courses in industry of last year students.

Promotion of the Materials Engineering Course and Biomaterials topics through regular collaboration in broadcasting programs, welcome days of students and teachers from national schools and scientific activities integrated in the Science & Technology National Program for young people .

Selected Publications (2010-2018)

 2018

 Book Chapter:Gil, A. M., Fernandes, M. H., & Duarte, I. F. (2019). Metabolomics in Biomaterial Research. In R. Narayan (Ed.), Encyclopedia of Biomedical Engineering, vol.3, pp. 432–442. Elsevier.ISBN: 9780128048290

 Barroca Nathalie, Ana Marote, Sandra I. Vieira, Abílio Almeida, Maria H.V. Fernandes, Paula M. Vilarinho and Odete A. B. da Cruz e Silva, “Electrically polarized PLLA nanofibers as neural tissue engineering scaffolds with improved neuritogenesis”, Colloids and Surfaces B: Biointerfaces, 167, 93-103, 2018.

Liliana Sofia Oliveira Pires, Maria Helena Figueira Vaz Fernandes, José Martinho Marques de Oliveira, "Crystallization kinetics of PCL and PCL-glass composites for Additive Manufacturing”, Journal of Thermal Analysis and Calorimetry,134-3, 2115-2125, 2018.

 Liliana Sofia Oliveira Pires, Maria Helena Figueira Vaz Fernandes, José Martinho Marques de Oliveira,  " Biofabrication of glass scaffolds by 3D Printing for tissue engineering" The International Journal of Advanced Manufacturing Technology, 98, Issue 9-12, 2665–2676, 2018

2017

Capela M.N., Tobaldi D.M., Oliveira C., Pereira A., Duarte A.S.., Seabra M.P., Fernandes M.H.V., “Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: effect of silver content and crystallinity”, Ceramics Internaional, 43, 13800–13809, 2017

2016

Book Chapter: Fernandes M.H.V,, Silva, A.M.B., “Glass-Ceramics - Concepts and Practical Aspects”,, Book title “Overall Aspects of Non-Traditional Glasses : Synthesis, Properties and Applications”, Chapter 3, pp  39-65, BENTHAM SCIENCE PUBLISHERS LTD, (2016), (eISBN: 978-1-68108-207-3; ISBN: 978-1-68108-208-0)

 Almeida J. Carlos, Wacha András, Gomes Pedro S, Alves Luís C, Fernandes M. Helena V, Fernandes M. Helena R, “A biocompatible hybrid material with simultaneous calcium and strontium release capability for bone tissue repair”, Materials Science and Engineering C, 62, 429–438, 2016

Almeida J. Carlos, Wacha András, Gomes Pedro S., Fernandes M. Helena R., Fernandes M. Helena Vaz, Salvado Isabel M. Miranda, “PDMS-SiO2-TiO2-CaO hybrid materials - biocompatibility and nanoscale surface features”, Materials Science and Engineering C, 64, 74–86, 2016

Fernandes João S., MartinsMargarida^,,NevesNuno M.^,, FernandesMaria H. V., Reis¹Rui L.^,, PiresRicardo A.^,* Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applications”, ACS Biomaterials Science & Engineering, 2 (7), pp 1143–1150, 2016

Marote A, Barroca N, Vitorino R, Silva RM, Fernandes MHV Vilarinho PM, Cruz e Silva OAB, Vieira SI "A proteomic analysis of the interactions between poly(L-Lactic Acid) nanofibers and SH-SY5Y neuronal-like cells” AIMS Molecular Science (special issue: Cells Signalling and Signal Transduction, 3(4), pp 661-682, 2016

2015:
Almeida J. Carlos, Lancastre Joana, Fernandes, M. Helena Vaz, Margaça Fernanda M. A.,Ferreira Luís, Salvado Isabel M. Miranda “Evaluating structural and microstructural changes of PDMS-SiO2 hybrid materials after sterilization by gamma irradiation”, Materials Science and Engineering C, 48, Pages 354–358, 2015

E.J.C. Davim, M.H.V. Fernandes and A.M.R. Senos, “Increased surface area during sintering of calcium phosphate glass and sodium chloride mixtures”, Journal of the European Ceramic Society, 35 (1), 329–336, 2015

J. Carlos Almeida, András Wacha, Attila Bóta, László Almásy, M.Helena V Fernandes, Fernanda A Margaça, Isabel Salvado, “PDMS-SiO2 hybrid materials - a new insight into the role of Ti and Zr as additives”, Polymer 72, 40-51, 2015.

Mihailova I. K., Radev L., Aleksandrova V. A., Colova I. V., Salvado I. M. M., Fernandes M. H. V., “Novel merwinite/akermanite ceramics: in vitro bioactivity”, Bulgarian Chemical Communications, Volume 47 (1), 253–260, 2015.

Irena Mihailova, Lachezar Radev , Verjinia Aleksandrova, Irena Colova, Isabel M.M. Salvado, Maria H.V. Fernandes, “Carbonate - apatite forming ability of polyphase glass - ceramics in the CaO - MgO - SiO2 system “, Journal of Chemical Technology and Metallurgy, 50, 4, 502-511, 2015.

ShiFa-Nian, Almeida JC., Helguero LA, Fernandes MHV, Knowles JC, Rocha J “Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders”, Inorganic Chemistry, 54 (20), 9929–9935, 2015

2014:

A.A.S. Lopes, R.C.C. Monteiro, R.S. Soares, M.M.R.A. Lima, M.H.V. Fernandes, “Crystallization kinetics of a barium-zinc borosilicate glass by a non-isothermal method”, Journal of Alloys and Compounds, Volume 591, 5, 268–274, 2014.

Almeida J. C., Castro A. G.B., Lancastre J. J. H., Miranda Salvado I.M.^,, Margaça F. M. A., Fernandes M. H. V., Ferreira L.M., Casimiro M. H. Structural characterization of PDMS-TEOS-CaO-TiO2 hybrid materials obtained by sol-gel”, Materials Chemistry and Physics, 148 (2) 557–563, 2014

Almeida, J. Carlos, Castro, António G. B., Miranda Salvado Isabel M., Margaça Fernanda M. A., Fernandes M. Helena Vaz “A new approach to the preparation of PDMS-SiO2 based hybrids - a structural study”, Materials Letters, 128, 105–109, 2014.

Vilarinho, Paula; Barroca, Nathalie; Zlotnik, Sebastian; Felix, Pedro; Fernandes , Maria Helena, “Are lithium niobate (LiNbO₃) and lithium tantalate (LiTaO₃) ferroelectrics bioactive?”, Materials Science and Engineerg C39, 395–402, , 2014.

Rocha, Rui J. M., Silva,  Ana M. B., Fernandes, M. Helena Vaz, Cruz, Igor C. S., Rosa ,Rui, Calado, Ricardo,  “Contrasting light spectra constrain the macro and microstructures architecture of scleractinian corals skeleton2, PLOS ONE, 9 (8), e105863, 2014

E.J.C. Davim, A.M.R. Senos and M.H.V. Fernandes,  “Non-isothermal crystallization kinetics of a Si-Ca-P-Mg bioactive glass”, Journal of Thermal Analysis and Calorimetry, 117:643–651, 2014

 Leite Ferreira B. J. M., Barroca N., Lopes P; Silva A; Fernandes M, Correia Rui, “Properties of novel PMMA-co-EHA bone cements filled with Hydroxyapatite”,: Polymer Composites, 55 (4),  759–767, 2014

2013:

P P Lopes, M S Silva and M H V Fernandes, “Influence of ibuprofen addition on the properties of a bioactive bone cement”, Journal of Materials Science: Materials in Medicine,  24(8), 2067-2076, 2013.

Lopes PP, Garcia MP, Fernandes MH, Fernandes MHV ”Acrylic formulations containing bioactive and biodegradable fillers to be used as bone cements: properties and cytocompatibility assessment”, Materials Science and Engineering C: Materials for Biological Applications, 33(3), 1289-1299, 2013

Nina E. Velikova, Yuliya E. Vueva, Yordanka Y. Ivanova, Yanko B. Dimitriev, Isabel M. Miranda Salvado, M. Helena F. V. Fernandes “Synthesis and Characterization of Hybrid Mesoporous Materials Prepared with Triblock-Copolymer and Bridged Silsesquioxane” International Journal of Materials and Chemistry, 3(3A): 21-28, 2013

Mariela T. Dimitrova, Yordanka Y. Ivanova, Yanko B. Dimitriev, Isabel M. Miranda Salvado, M. Helena F. V. Fernandes, “ Nanostructured Float-Glasses after Ion-exchange in Melts Containing Silver or Copper Ions”, International Journal of Materials and Chemistry, 3(3A): 29-38, 2013.

Lopes PP, Garcia MP, Fernandes MH, Fernandes MHV, “Properties and osteoblast cytocompatibility of self-curing acrylic cements modified by glass fillers”, Journal of Biomaterials Applications, 28 (4), 498-513, 2013.

Radev L, Vladov D, Michailova, I, Cholakova, E, Fernandes, MHV, Salvado IMM "In vitro Bioactivity of Polycaprolactone/Bioglass Composites”, International Journal of Materials and Chemistry, 2013, 3(5): 91-98 (open access)

Vueva, Y, Ivanova, Y, Salvado, I, Fernandes, M, Vassileva, P, Georgieva, R, Detcheva, A, “Synthesis and characterization of sol–gel mesoporous organosilicas functionalized with amine groups”, Journal of Non-Crystalline Solids, 378, 89-95, 2013.

Velikova NE, Vueva YE, Abdallah ME, Ivanova YY., Dimitriev YB, Salvado IM, Fernandes MHV, “Nanoporous Ceramic hybrid materials synthesized by organically modified ceramic precursor with terminal amine group”, Journal of International Scientific Publications: Materials, Methods &Technologies,Volume 7,Part 1, 388-399, 2013

Nina E. Velikova, Yuliya E. Vueva, Yordanka Y. Ivanova, Yanko B. Dimitriev, Isabel M. Miranda Salvado, M. Helena F. V. Fernandes, “Synthesis and Characterization of Hybrid Mesoporous Materials Prepared with Triblock-Copolymer and Bridged Silsesquioxane, International Journal of Materials and Chemistry, 3(3A): 21-28, 2013 (open access)

Daguano JK MF, Suzuki PA., Strecker K, Oliveira JMM, Fernandes, MHV, Santos, C, Development and characterization of 3CaO·P2O5–SiO2–MgO glass-ceramics with different crystallization degree, Journal of Advanced Ceramics, , 2(4): 378–388, 2013

2012:

Book Chapter: Fernandes M.H.V.,  Senos A.M. R., Oliveira J.M.  

 “Scaffolds de vidros bioactivos para medicina regenerative”, In VIDRIOS Y VITROCERÁMICOS BIOACTIVOS. NUEVOS RETOS HACIA LA MEDICINA REGENERATIVA, Editorial Netbiblo, Editors HÉLIO AGUIAR,   JULIA SERRA,  PÍO GONZÁLEZ, 87-108. ISBN 978849745176-5

Barroca N, Vilarinho  PM, Fernandes MHV, Sharma P , Gruverman A, “Stability of electrically induced-polarization in PLLA for bone regeneration”, Aplied Physis Letters, 101, 023701, 2012

Daguano JKMF, Strecker K, Ziemath EC, Rogero, SO, Fernandes MHV,Santos C “Effect of partial crystallization on the mechanical properties and cytotoxicity of bioactive glass from the 3CaO.P2O5-SiO2-Mgo system”, Journal of the Mechanical Behavior of Biomedical Materials, 14, 78-88, 2012

Daguano, J.K.M.F., Suzuki, P.A., Strecker, K., Fernandes,M.H.F.V., Santos, C.  “Evaluation of the micro-hardness and fracture toughness of amorphous and partially crystallized 3CaO.P2O5-SiO2-MgO bioglasses”, Materials Science and Engineering A, 533, 26-32,      2012

Lopes PP, Garcia MP, Fernandes MH, Fernandes MHV, “Properties and osteoblast cytocompatibility of self-curing acrylic cements modified by glass fillers”, Journal of Biomaterials Applications, PDMID 22918184 DOI:10.1177/0885328212457097, 2012     

Lopes PP, Garcia MP, Fernandes MH, Fernandes MHV”Acrylic formulations containing bioactive and biodegradable fillers to be used as bone cements: properties and cytocompatibility assessment”, Materials Science and Engineering C, DOI 10.1016/j.msec.2012.12.028, 2012

Monteiro RCC, Lopes AAS, Lima MMA, Veiga JP, Silva RJC, Dias CJ, Davim EJR, Fernandes MHV, “Sintering, crystallization and dielectric behaviour of BaO-ZnO-B2O3-SiO2 glasses: Effect of BaO substitution for ZnO”, Journal of the American Ceramic Society, 95 (10), 3144–3150,  2012 

Castro A G B, Almeida J C, Miranda Salvado I M, Margaça F M A, Fernandes M H V, “A novel hybrid material with calcium and strontium release capability”, Materials Letters, 88, 12-15, 2012

Radev L, Hristova K, Jordanov V, Fernandes M H V, Miranda Salvado I M, “In vitro bioactivity of 70wt% SiO₂-30wt%Cao sol-gel glass doped with 1,3 and 5wt% NbF₅”, Central European Journal of Chemistry, 10, 137-145, 2012

Leite Ferreira BJ, Duarte MG, Gil, MH, Fernandes MH, Nunes Correia R, ”Influence of albumin on mineralization of PMMA-based/glass composites”, J Appl Biomater & Function Mater. 10(2) 92-9 2012

Bandeira LC , Ciuffi KJ, Calefi PS, Nassar EJ, Silva,JVL, Oliveira M, Maia IA , Salvado IM, Fernandes MHV, “Effect of Calcium Phosphate Coating on Polyamide Substrate for Biomaterial Applications”,  J. Braz. Chem. Soc., Vol. 23 (5), 810-817, 2012

Lancastre J J H, Margaça F M A, Ferreira L M, Falcão A N, Miranda Salvado I M, Nabiça M S M S, Fernandes M H V, Almásy L “Thermal analysis and SANS characterisation of hybrid materials for biomedical applications”, J. of Thermal Analysis and Calorimetry, 109, 413-418, 2012

Santos, F.A., Santos, C., Rodrigues D. Jr, Pinatti D. G., Davim, E., Fernandes M. H. V., “Lithium Disilicate Bioceramic Obtained from Alternative Silica Source, the Rice Husk”, Materials Science Forum Vols. 727-728, 1158-1163, 2012

Barroca, N; Vieira, S; Silva, ODE; Gomes, P; Fernandes, H; Fernandes, H; Vilarinho, P, “Piezoelectric polymers for tissue regeneration: neural and bone tissues approaches”, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 203-203, 2012

Luis, JL; Costa, ME; Fernandes, MHV; Vieira, SI; Silva, OABCE, “Selective osteoblastic citotoxicity induced by nanostructured ZnO in PU /ZnO composites, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 207-207, 2012

2011:

Barroca , N., Vilarinho , P.M., Daniel-da-Silva , A.L., Aiying, W., Fernandes, M.H., Gruverman, A., "Protein Adsorption on Piezoelectric Poly (L-lactic) Acid Thin Films by Scanning Probe Microscopy", Aplied Physis Letters, 98, 133705, 2011

Lopes PP, Leite Ferreira BJM, Gomes PS, Correia RN, Fernandes MH, Fernandes MHV "Silicate and borate glasses as composite fillers: a bioactivity and biocompatibility study". Journal of Materials Science: Materials in Medicine, 22, 1501-1510, 2011

Silva AMB, Queiroz CM, Agathopoulos S, Correia RN, Fernandes MHV, Oliveira JM “Structure of SiO₂-MgO-Na₂O glasses by FTIR, Raman and ²⁹Si MAS NMR”, Journal of Molecular Structure, 986 (1-3), 16, 2011

Rangelova N, Radev L, Nenkova S, Miranda Salvado I M, Fernandes M H V, Herzog M, “Methylcellulose/SiO2 hybrids: sol-gel preparation and characterization by XRD, FTIR and AFM”, Central European Journal of Chemistry, 9 (1) 112-118,  2011

Chernev G, Rangelova N, Djambazki, Nenkova S, , Salvado I, Fernandes M, Wu A, Kabaivanova L, “Sol-gel silica hybrid biomaterials for application in biodegradation of toxic compounds”, Journal of Sol-Gel Science and Technology, 58, 619-624, 2011  

Kabaivanova L V, Chernev G E, Miranda Salvado I M, Fernandes M H V, “Sílica-carrageenan hybrids used for cell immobilization realizing high-temperature degradation of nitrile substrates”, Central European Journal of Chemistry, 9 (2) 232-239,  2011

L. C. Bandeira, P. S. Calefi, K. J. Ciuffi, E. J. Nassar, I. M. M. Salvado, M. H. F. V. Fernandes  Low temperature synthesis of bioactive materials”, Cerâmica 57, 166-172, 2011

L. Radev, V. Hristov, I. Michailova, M. H. V. Fernandes, I. M. M. Salvado, Collagen silicocarnotite-composites, cross-linked with Chondroitin Sulphate: in vitro bioactivity“ , Processing and Application of Ceramics, 5 [3], 161-170, 2011

2010:

Silva, A. M. B., Oliveira, J. M. M., Correia, R. N.,  Fernandes, M. H. V., “Structural Characterization of TiO₂-P₂O₅-CaO Glasses by Spectroscopy”, Journal of the European Ceramic Society 30, 1253–1258, 2010

Barroca , N., Daniel-da-Silva , A.L., Vilarinho , P.M., Fernandes, M.H.V.,“Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass additions”, Acta Biomaterialia 6 3611–3620, 2010

Elisa, M., Sava, B.A., Volceanov, A., Monteiro, R.C.C., Alves, E., Franco, N., Costa, Oliveira, F.A., Fernandes,H., Ferro, M., " Structural and thermal characterization of SiO2–P2O5 sol–gel powders upon annealing at high temperatures”, Journal of Non-Crystaline Solids, 356 , pp 495–501, 2010

Lachezar Radev, Hristov, V, Fernandes, MHV, Salvado, IMM, , “Organic/Inorganic bioactive materials Part IV: in vitro assessment of bioactivity of gelatin/calcium phosphate silicate/wolastonite hybrids, Central European Journal of Chemistry, 8(2), 278–284, 2010

Ts. Gerganova, Y. Ivanova, Y. Vueva, Isabel M Salvado. and Maria Helena Fenandes, Crystallization behaviour of nanostructured hybrid SiO2-TiO2 gel glasses to nanocomposites” J. Nanosci. Nanotechnol. 10 (4), 2444–2450,2010

Lachezar Radev1, Vladimir Hristov1, Irena Michailova, Maria Helena V. Fernandes, Isabel Miranda M. Salvado, “In vitro bioactivity of biphasic calcium phosphate silicate glassceramic in CaO-SiO2-P2O5 system”, Processing and Application of Ceramics 4(1), pp15-24, 2010

Daguano, J.K.M.F., Santos, C., Suzuki, P.A., Bicalho, L.A., Fernandes,M.H.F.V. “Improvement of the Mechanical Properties of Glasses based on the 3CaO.P2O5-SiO2-MgO System after Heat-Treatment”, Materials Science Forum Vols. 636-637, pp 41-46, 2010

Yordanka, I., Tsvetelina, G., Vueva, Y., Fernandes, MH, Salvado, IMM , “ZrO2 nanocomposites from polyzirconosiloxanes”, Int. J. Nanomanufacturing, Vol. 5, Nos. 1/2, pp 152-162, 2010