Preparation method of polymer-based composite porous structures for tissue engineering application

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Patent Details

Publication Number
PT104136
Priority Date
2008-07-22
Publication Date
2010-01-22
International Patent Classification
A61L27/44
A61L27/56
C12N 5/08

Figures

figura
SEM micrographs of porous composite structures prepared with 10% (a) and 50% (b) (wt/wt) of glass filler. (Average pore size is respectively ~35 μm and ~150 μm).

Abstract

The present invention relates to a method for preparing composite porous structures, of polymeric matrix and inorganic filler, biocompatible and biodegradable for tissue engineering applications. In particular, the present invention describes the use of inorganic bioactive compounds of different solubility to induce and control the porosity of  porous polymeric scaffolds prepared by thermally induced liquid-liquid phase separation.

Innovative aspects & main advantages

In this invention it is described a method by which it is possible to induce and control the porosity of porous polymeric composite scaffolds. The novelty lies in the fact that such control can be performed by varying the water-solubility of the bioactive inorganic filler, which is usually added for other purposes, such as to confer bioactivity to the system and improve its mechanical properties.
The solubility is controlled not only by the composition of the bioactive inorganic phase but also by the residence time of this phase in the aqueous medium during the preparation of the support and by the temperature at which the process takes place. An additional advantage of this method over the known so far is that it eliminates the need to introduce additional compounds as porogen to induce and control the porosity of the final structure. It is the bioactive inorganic phase that acts by itself as a porogen, besides enhancing the mechanical properties of the porous structure and confer bioactivity.

Applications

Biomaterials; biomedical devices.

Inventors

Fernandes, Maria; Vilarinho, Paula; Silva, Ana; Barroca, Natália

Our Inventors

foto Ana Luísa Daniel da Silva

Ana Luísa Daniel da Silva

Principal Researcher
foto Maria Helena Figueira Vaz Fernandes

Maria Helena Figueira Vaz Fernandes

Retired Professor
foto Natália Braz Barroca

Natália Braz Barroca

PhD Student
foto Paula Maria Lousada Silveirinha Vilarinho

Paula Maria Lousada Silveirinha Vilarinho

Vice Director

Applicant

Universidade de Aveiro

Groups Involved

G1 - Porous Materials and Nanosystems
G2 - Photonic, Electronic and Magnetic Materials
G5 - Biomimetic, Biological and Living Materials

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