Description
InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expected to be obtained. A double network photocrosslinkable biomaterial system based on human plasma-derived Platelet Lysates (PL) will be used as base matrix. The PL-based hydrogels will be further combined with mechanically reinforcing biomaterials, namely CaP-based bioceramics and PCL-LA polymers, to produce bone-like and fibrous structures, respectively, and will be able to be blended with natural drug carriers (flavonoid-loaded nanomicelles). Compositional and structural variations will be enabled by combining photo-assisted printing and MEW/ESP in a single-step hybrid AM process. New computational tools will support the mechanobiological optimization of all biomaterials and final parts, as well as the AM process design. Superior biofunctionality of the InterLynk’ scaffolds will be validated in an highly complex multi-tissue interfacial biosystem, the temporomandibular joint.
InterLynk will implement comprehensive strategies to engage key groups of stakeholders (clinical, engineering, regulatory and market-related) in the development of biological scaffolds, establishing a truly multidisciplinary co-creation process. These scaffolds are expected to have no counterpart in both fabrication and multi-tissue regeneration, avoiding time-consuming and costly procedures in both dimensions. This will increase current AM (bio)fabrication capabilities and application range, widely extending its use. Their high flexibility and unique performance will considerably reduce immune rejection, risk of contamination and, inherently, rehabilitation time of multi-tissue injuries resulting in increasing wellbeing and healthcare costs reduction.
Coordinator
Coordination
Universidade de Aveiro (UA)
Partners
METATISSUE - BIOSOLUTIONS, LDA., ENVISIONTEC GMBH, UNIVERSITEIT MAASTRICHT, CHARITE - UNIVERSITAETSMEDIZIN BERLIN, KUROS BIOSCIENCES BV, PROMOSCIENCE SRL, INEGI
Groups
G3 - Electrochemical Materials, Interfaces and Coatings;
G5 - Biomimetic, Biological and Living Materials;
Outputs
Simulating 3D printing on hydrogel inks: A finite element framework for predicting mechanical properties and scaffold deformation
Pouca, MCPV; Cerqueira, MRG; Ferreira, JPS; Darabi, R; Ramiao, NAG; Sobreiro-Almeida, R; Castro, APG; Fernandes, PR; Mano, JF; Jorge, RMN; Parente, MPL3D-printed injectable nanocomposite cryogel scaffolds for bone tissue regeneration
Castanheira, EJ; Maia, JR; Monteiro, LPG; Sobreiro-Almeida, R; Wittig, NK; Birkedal, H; Rodrigues, JMM; Mano, JFCryogels Composites: Recent Improvement in Bone Tissue Engineering
Castanheira, EJ; Rodrigues, JMM; Mano, JFLeveraging Blood Components for 3D Printing Applications Through Programmable Ink Engineering Approaches
Sobreiro-Almeida, R; Santos, SC; Decarli, MC; Costa, M; Correia, TR; Babilotte, J; Custódio, CA; Moroni, L; Mano, JFBioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP-Based Particles and 3D-Printed Scaffolds
Carvalho, TSS; Torres, PMC; Belo, JH; Mano, J; Olhero, SMEngineering natural based nanocomposite inks via interface interaction for extrusion 3D printing
Maia, JR; Castanheira, E; Rodrigues, JMM; Sobreiro-Almeida, R; Mano, JFInfluence of structural features in the performance of bioceramic-based composite scaffolds for bone engineering applications: A prediction study
Rosa, N; Pouca, MV; Torres, PMC; Olhero, SM; Jorge, RN; Parente, MBiomaterials of human source for 3D printing strategies
Maia, JR; Sobreiro-Almeida, R; Cleymand, F; Mano, JFProgrammable Granular Hydrogel Inks for 3D Bioprinting Applications
Ribeiro, LS; Gaspar, VM; Sobreiro-Almeida, R; Camargo, ER; Mano, JFDouble-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures
Gonçalves, L; Lavrador, P; Amaral, AJR; Ferreira, LP; Gaspar, VM; Mano, JFCore-shell microcapsules: biofabrication and potential applications in tissue engineering and regenerative medicine
Ladeira, BM; Custodio, CA; Mano, JFUniversal Strategy for Designing ShapeMemory Hydrogels
Costa, DCS; Costa, PDC; Gomes, MC; Chandrakar, A; Wieringa, PA; Moroni, L; Mano, JFAdvanced hydrogels based on natural macromolecules: chemical routes to achieve mechanical versatility
Mortier, C; Costa, DCS; Oliveira, MB; Haugen, HJ; Lyngstadaas, SP; Blaker, JJ; Mano, JFBone: An Outstanding Composite Material
Rosa, N; Moura, MFSF; Olhero, S; Simoes, R; Magalhaes, FD; Marques, AT; Ferreira, JPS; Reis, AR; Carvalho, M; Parente, MNatural Origin Biomaterials for 4D Bioprinting Tissue-Like Constructs
Costa, PDC; Costa, DCS; Correia, TR; Gaspar, VM; Mano, JFSponsors
