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Descrição
Ribonucleic acid (RNA) molecules are gaining momentum for the treatment of various conditions including in the generation of antiviral vaccines. However, RNA production relies on costly in vitro transcription methods. The EU-funded Yscript project proposes an alternative method for production of messenger RNA (mRNA) molecules, using yeast. Given the similarity in the structure between yeast and human mRNA, researchers will set up a technology for producing, isolating and purifying mRNA in yeast cells. This bioproduction platform will guarantee high purity and stability of target mRNA molecules – at a fraction of the cost. Importantly, it will lay the foundation for advancing the use of RNA therapeutics in medicine.
Coordenador
Coordenação
Centre national de la recherche scientifique (CNRS)
Participantes
BIA SEPARATIONS D.O.O EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH (EURICE) INRAE - INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK (ICBPAN) TRON - TRANSLATIONALE ONKOLOGIE ANDER UNIVERSITATSMEDIZIN DER UNIVERSIDADE DA BEIRA INTERIOR UNIVERSIDADE DE AVEIRO
Grupos
G5 - Materiais Biomiméticos, Biológicos e Vivos;
G4 - Materiais Renováveis e Economia Circular;
Resultados
Multimodal ionic liquid-based chromatographic supports for an effective RNA purification
Carapito, R; Bernardo, SC; Pereira, MM; Neves, MC; Freire, MG; Sousa, FUnveiling the potential of deep eutectic solvents to improve the conformational and colloidal stability of immunoglobulin G antibodies
Dhiman, D; Marques, ASC; Bisht, M; Tavares, APM; Freire, MG; Venkatesu, PFinanciadores
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