Yeast cell factory for mRNA bioproduction

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Project Details

Start date
2022-04-01
End date
2025-03-31
%
Acronym
Yscript
Reference
101047214
Funding
European Comission
Programme
HORIZON-EIC-2021-PATHFINDEROPEN-01
Budget
3.078.250 €
Our budget
303.974 €

Team

Description

Ribonucleic acid (RNA) molecules are gaining momentum for the treatment of various conditions including in the generation of antiviral vaccines. However, RNA production relies on costly in vitro transcription methods. The EU-funded Yscript project proposes an alternative method for production of messenger RNA (mRNA) molecules, using yeast. Given the similarity in the structure between yeast and human mRNA, researchers will set up a technology for producing, isolating and purifying mRNA in yeast cells. This bioproduction platform will guarantee high purity and stability of target mRNA molecules – at a fraction of the cost. Importantly, it will lay the foundation for advancing the use of RNA therapeutics in medicine.

Main Local Researcher

Mara Guadalupe Freire Martins

Coordination

Centre national de la recherche scientifique (CNRS)

Partners

BIA SEPARATIONS D.O.O EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH (EURICE) INRAE - INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK (ICBPAN) TRON - TRANSLATIONALE ONKOLOGIE ANDER UNIVERSITATSMEDIZIN DER UNIVERSIDADE DA BEIRA INTERIOR UNIVERSIDADE DE AVEIRO

Groups

G5 - Biomimetic, Biological and Living Materials;
G4 - Renewable Materials and Circular Economy;

link

https://www.yscript.eu/

Outputs

Sponsors

Sponsors
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