By-products of Scyliorhinus canicula, Prionace glauca and Raja clavata: A valuable source of predominantly 6S sulfated chondroitin sulfate
authors Novoa-Carballal, R; Perez-Martin, R; Blanco, M; Sotelo, CG; Fassini, D; Nunes, C; Coimbra, MA; Silva, TH; Reis, RL; Vazquez, JA
nationality International
journal CARBOHYDRATE POLYMERS
author keywords Chondroitin sulfate; Elasmobranch; Scyliorhinus canicula; Prionace glauca; Raja clavata; Sulfation position
keywords SIZE-EXCLUSION CHROMATOGRAPHY; HYALURONIC-ACID; URONIC-ACIDS; CARTILAGE; GLYCOSAMINOGLYCANS; CHITOSANS; PROTEINS
abstract Chondroitin sulfate (CS) was isolated from Scyliorhinus canicula (fin, head and skeleton), Prionace glauca (head), and Raja clavata (skeleton) by-products from fish processing industry using environmentally friendly processes. The molecular weight was determined by gel permeation chromatography and the sugar composition and sulfation position by NMR and SAX-HPLC after enzymatic digestion. The CSs showed a prevalent 6S GaINAc sulfation for the 3 species (4S/6S ratio lower than 1). A higher 6S sulfation was observed for P. glauca head and R. clavata skeleton (4S/6S ratio below 0.20) than for S. canicula (4S/6S ratio ca. 0.6). The existence of CS samples with such low 4S/6S ratio has only been observed before in a rare species of shark (Mitsukutina owatoni, globin shark). The good extraction yields achieved make S. canicula, P. glauca and R. clavata fish industry by-products a useful source of 6-sulfated chondroitin sulfate. (C) 2016 Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0144-8617
isbn 1879-1344
year published 2017
volume 157
beginning page 31
ending page 37
digital object identifier (doi) 10.1016/j.carbpol.2016.09.050
web of science category Chemistry, Applied; Chemistry, Organic; Polymer Science
subject category Chemistry; Polymer Science
unique article identifier WOS:000391896800004
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