abstract
In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most photo-toxic (at 2.5 mu M) towards B16F10 cells.
keywords
SINGLET OXYGEN GENERATION; BODIPY DYES; AZADIPYRROMETHENE COMPLEXES; PHOTOPHYSICAL PROPERTIES; THERAPY; NANOPARTICLES; ACCEPTORS; ZINC
subject category
Biochemistry & Molecular Biology; Biophysics; Chemistry
authors
Castro, KADF; Costa, LD; Guieu, S; Biazzotto, JC; Neves, MDPMS; Faustino, MAF; da Silva, RS; Tome, AC
our authors
Samuel Jacques André Guieu
Junior Researcheracknowledgements
Thanks are due to Fundacao para a Ciencia e a Tecnologia (FCT) for the financial support to project PTDC/QEQ-QOR/6160/2014, the QOPNA research project (FCT UID/QUI/00062/2019) and the LAQV-REQUIMTE (UIDB/50006/2020), the project CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT UID/CTM/50011/2019), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement. Thanks also to Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-2016/12707-0), Universidade de Sao Paulo. L. D. Costa thanks FCT for her doctoral grant (SFRH/PD/BD/114578/2016). S. Guieu acknowledges the funding from national funds (OE), through FCT -, in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19, and from the Integrated Programme of SR&TD pAGE - Protein aggregation Across the Lifespan (reference CENTRO-01-0145-FEDER-000003). K. A. D. F. Castro thanks PNPD/CAPES for her postdoctoral grant.