abstract
Poly(glycerol sebacate) (PGS) is a biodegradable elastomer that has attracted increasing attention as a potential material for applications in biological tissue engineering. The conventional method of synthesis, first described in 2002, is based on the polycondensation of glycerol and sebacic acid, but it is a time-consuming and energy-intensive process. In recent years, new approaches for producing PGS, PGS blends, and PGS copolymers have been reported to not only reduce the time and energy required to obtain the final material but also to adjust the properties and processability of the PGS-based materials based on the desired applications. This review compiles more than 20 years of PGS synthesis reports, reported inconsistencies, and proposed alternatives to more rapidly produce PGS polymer structures or PGS derivatives with tailor-made properties. Synthesis conditions such as temperature, reaction time, reagent ratio, atmosphere, catalysts, microwave-assisted synthesis, and PGS modifications (urethane and acrylate groups, blends, and copolymers) were revisited to present and discuss the diverse alternatives to produce and adapt PGS.
keywords
POLY GLYCEROL-SEBACATE; MECHANICAL-PROPERTIES; BIOMEDICAL APPLICATIONS; ENZYMATIC DEGRADATION; ALIPHATIC POLYESTERS; CATALYZED SYNTHESIS; FIBROUS SCAFFOLDS; DIVINYL SEBACATE; ELASTOMER; FABRICATION
subject category
Biotechnology & Applied Microbiology; Science & Technology - Other Topics
authors
Godinho, B; Gama, N; Ferreira, A
our authors
Artur Jorge Faria Ferreira
Professor Coordinator
Bruno Miguel Marques Godinho
Researcher
Nuno Vasco da Costa Gama Batista de Melo
Junior ResearcherProjects
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
acknowledgements
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020), financed by national funds through the FCT/MEC (PIDDAC).