Microparticles orchestrating cell fate in bottom-up approaches


The modulation of cells in tissue formation is still one of the hardest tasks to achieve in Tissue Engineering. To control the cell response when undergoing their normal functions such as adhesion, differentiation, assembly, or maturation is vital the development of more successful solutions. Herein, we discuss how microparticles are being overlooked in their potential for controlling the cellular response. Until now, their role was quite often restricted to a reservoir of chemical compounds or as carriers for cell expansion. Nevertheless, microparticles design with the introduction of biophysical and biochemical cues can effectively modulate cell response.



subject category

Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology


Maciel, MM; Correia, TR; Henriques, M; Mano, JF

our authors


The authors would like to acknowledge the financial support from the European Research Council (ERC) for project ATLAS (ERC2014-ADG-669858) and the Portuguese Foundation for Science and Technology (FCT) through the PhD grant PD/BD/139117/2018 (M.M. Maciel). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the Foundation for Science and Technology/MCTES.

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