Fabrication of highly stretchable hydrogel based on crosslinking between alendronates functionalized poly-gamma-glutamate and calcium cations


We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-gamma-glutamate (gamma-PGA), a typical biodegradable polymer. gamma-PGA with ALN (gamma-PGA-ALN) forms the hydrogel in the aqueous solution containing CaCl2. The hydrogel shows 2000% of stretchability and reversible stretching without failure at a strain of 250%. The fracture strain and stress are tunable by varying the concentration of either gamma-PGA-ALN or CaCl2, indicating the importance of fine-tuning of the density of the cross-linkage to control the mechanical properties of the hydrogel. We believe the biode-gradable polymer based highly stretchable hydrogel has potential for use in various fields such as tissue engineering.



subject category

Engineering; Materials Science


Nakamoto, M; Noguchi, M; Nishiguchi, A; Mano, JFF; Matsusaki, M; Akashi, M

our authors


Acknowledgements The authors acknowledge financial support by Grant-in-Aid for Sci-entific Research (A) (20H00665) and Grant-in-Aid for Start-up (20K22499) from JSPS, and Bilateral Programs between JSPS and DAAD (JPJSBP 120213505) .

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