Nephrotoxicity of CCA-treated wood: A comparative study with AS(2)O(5) and CrO3 on mice


The purpose of this work was to assess the acute toxicity on male mice to a chromated copper arsenate (CCA) solution, a widespread wood preservative used in building industry until 2002. Animals were subcutaneously injected with CCA (7.2 mg/kg arsenic and 10.2 mg/kg chromium per body weight) CrO3, (10.2 mg/kg), As2O5 (7.2 mg/kg) and NaCl (0.9%) per se, during 48 h and 96 h. for histopathology, histochemistry. chromium and arsenic analysis. The results showed some histopathological changes within renal tubules lumen of CCA exposed animals (during 48 h, and 96 h), and CrO3 (for the period of 96 h). Furthermore, the renal levels of arsenic and chromium in treated animals were statistically more evident than controls. Although, the same contents of pentavalent arsenic and hexavalent chromium were injected into treated animals with CCA and with the prepared solutions of AS(2)O(5) and CrO3, a different distribution of the pattern of these compounds was observed in kidneys. (C) 2008 Elsevier B.V. All rights reserved.



subject category

Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology


Matos, RC; Vieira, C; Morais, S; Pereira, MD; de Jesus, JP

our authors


Grants for this work were provided in part by the Research Centre on Ceramic and Composite Materials (CICECO) from Aveiro University (Portugal). Authors wish to express their gratitude to Dr. Cristina Delerue-Matos for allowing the use of the equipments for arsenic and chromium quantitative analysis.

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