abstract
The present study investigated the in vitro performance of brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements in terms of wet mechanical strength and biological response. Quantitative phase analysis and structural refinement of the powdered samples were performed by Xray powder diffraction and Rietveld refinement technique. Initial and final setting times of the cement pastes, measured using Gilmore needles technique, showed that ZnSrCPC sets faster than ZnCPC. The measured values of the wet strength after 48 h of immersion in PBS solution at 37 degrees C showed that ZnSrCPC cements are stronger than ZnCPC cements. Human osteosarcoma-derived MG63 cell line proved the nontoxicity of the cement powders, using the resazurin metabolic assay. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 948: 414-420, 2010.
keywords
CALCIUM-PHOSPHATE CEMENT; TO-POWDER RATIO; TRICALCIUM PHOSPHATE; BIPHASIC HYDROXYAPATITE; OSTEOBLASTIC CELLS; CRYSTAL-STRUCTURE; APATITE CEMENT; STRONTIUM; INJECTABILITY; VIVO
subject category
Engineering; Materials Science
authors
Pina, S; Vieira, SI; Torres, PMC; Goetz-Neunhoeffer, F; Neubauer, J; Silva, OABDE; Silva, EFDE; Ferreira, JMF
our authors
José Maria da Fonte Ferreira
Retired Professor
Paula Maria da Costa Torres
Assistant Researcheracknowledgements
Contract grant sponsor: Portuguese Foundation for Science and Technology; contract grant numbers: REEQ/1023/BIO/2005, SFRH/BD/21761/2005, SFRH/BPD/19515/2004, SFRH/BD/62021/2009; Contract grant sponsor: CICECO