Ongoing Supervisions
Projects
Exploring devitalized MSCs fibres as immunomodulatory devices for wound regeneration through (i) direct promotion of healing or (ii) enabling of allograft transplantation free of systemic immunosuppression (LAZARUS)
CoordinatorOther International
The project aims at exploring MSCs as constituents of off-the-shelf easy-to-handle immunomodulatory biomaterials. The project focuses on using these materials to treat difficult-to-heal wounds, which may be chronic, or have proneness to become chronic if not properly treated.Two treatment approaches will be explored using devitalized MSC aggrega...Hybrid living bioengineered hierarchical constructs with self-oxygenating capability (O2CELLS)
PartnerFundação para a Ciência e a Tecnologia
Tissue engineering (TE) has emerged as an alternative solution aiming to provide a surplus of temporary structural supports at the defect site until native tissue is endogenously regenerated and normal function is restored. Although progresses have been made in the last 20 years, it is not yet possible to address all the complexity and (multi)fu...Innovative tools to treat and model complex cancer environments (TheraTools)

PartnerEuropean Comission
Funded by the Marie Skłodowska-Curie Actions programme, the TheraTools project will create a multidisciplinary research and training network to focus on the technological development of scientific tools to study malignant tumours localised beyond a biological barrier, as in the case of brain tumours. The TheraTools consortium will provi...Merging Sustainable and Digital Chemical Technologies for The Development of Greener-Bydesign Pharmaceuticals (SusPharma)

PartnerEuropean Comission
Safe- and green-by-design are pre-market design approaches whereby the objectives of minimizing the use of hazardous chemicals, reducing greenhouse gas emissions, and fostering the reuse and recycling of materials in a circular economy are built into product design. SUSPHARMA fits the European need for sustainable development in modern ...Metabolite-activated 3D stem cell differentiation into bone (BetterBone)
PartnerFundação para a Ciência e a Tecnologia
Strategies involving mesenchymal stem cell (MSC) osteogenic differentiation have emerged as promising tools in regenerative medicine. These work by either promoting in situ regeneration, or through newly-fabricated tissue grafts, potentially overcoming clinical complications related to more conventional therapies. However, bioengineered ...A Metabolomics-guided Bioreactor for Improved Engineered Bone Implants (BioImplant)
PartnerFundação para a Ciência e a Tecnologia
Advancing the Regenerative and Translational Potential of Cellular Fibers (CellFi)
CoordinatorFundação para a Ciência e a Tecnologia
Mesenchymal Stem Cells Scaffold-free Cellular Fibers RegenerationCápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)
PartnerFundação para a Ciência e a Tecnologia
Desenvolvimento de hidrogeis de inspiracao marinha multifuncionais e de elevado desempenho para regeneracao de cartilagem, reticulados com ligacoes nao-covalentes e bio-instrutivas deslizantes. (MARGEL)
PartnerFundação para a Ciência e a Tecnologia
Development and testing of multifunctional carriers based on micro- and nanoscale engineering for targeted, controlled, and safe delivery of agrochemicals to crops (Agritarget)
PartnerFundação para a Ciência e a Tecnologia
Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)
PartnerFundação para a Ciência e a Tecnologia
Publications
An Intracellular Metabolic Signature as a Potential Donor-Independent Marker of the Osteogenic Differentiation of Adipose Tissue Mesenchymal Stem Cells
Bispo, DSC; Jesus, CSH; Romek, K; Marques, IMC; Oliveira, MB; Mano, JF; Gil, AM
2022, CELLS, 11, 23.
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Cell Response in Free-Packed Granular Systems
Cunha, AF; Matias, AFV; Dias, CS; Oliveira, MB; Araujo, NAM; Mano, JF
2022, ACS APPLIED MATERIALS & INTERFACES, 14, 36, 40469-40480.
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Cell Response in Free-Packed Granular Systems
Ana F. Cunha, André F. V. Matias, Cristóvão S. Dias, Mariana B. Oliveira*, Nuno A. M. Araújo*, João F. Mano*
2022, ACS Applied Materials & Interfaces, 14, 36, S417-S418.
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Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation
Bispo, DSC; Michalkova, L; Correia, M; Jesus, CSH; Duarte, IF; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2022, CELLS, 11, 8.
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NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells
Bispo, DSC; Jesus, CSH; Correia, M; Ferreira, F; Bonifazio, G; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2022, JOURNAL OF PROTEOME RESEARCH, 21, 3, 654-670.
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ONE-STEP ASSEMBLY OF ROBUST ALL-CELLULAR FIBERS
Oliveira, MB; Salvador, T; Sousa, AR; Mano, JF
2022, TISSUE ENGINEERING PART A, 28, S398-S398.
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Tricalcium phosphate doped with Mg2+ and combinations of Mn2+, Zn2+ and Fe3+: A DoE study on sintering, mechanical, microstructural and biological properties
Macedo, DF; Cunha, AF; Mano, JF; Oliveira, MB; Silva, AP
2022, CERAMICS INTERNATIONAL, 48, 14, 20467-20477.
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Recent advances in the design of implantable insulin secreting heterocellular islet organoids
Akolpoglu, MB; Inceoglu, Y; Bozuyuk, U; Sousa, AR; Oliveira, MB; Mano, JF; Kizilel, S
2021, BIOMATERIALS, 269.
ISBN:
1878-5905
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Engineering Strategies for Allogeneic Solid Tissue Acceptance
Sousa, AR; Mano, JF; Oliveira, MB
2021, TRENDS IN MOLECULAR MEDICINE, 27, 6, 572-587.
ISBN:
1471-499X
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Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
Goncalves, RC; Banfi, A; Oliveira, MB; Mano, JF
2021, BIOMATERIALS, 269.
ISBN:
1878-5905
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