Ongoing Supervisions
João António Abreu Pereira
PhD Student
Patrícia Coelho Vigário
Research FellowshipProjects
A bioprinting platform for the rapid, reliable, controlled and quantifiable patterning of cellular aggregatesand microtissues into macroscale regenerative grafts with programmable architectures (m2M)
PartnerEuropean Comission
A fundamental limitation with current approaches aiming to bioprint tissues and organs is an inability to generate constructs with truly biomimetic composition and structure, resulting in the development of engineered tissues that cannot execute their specific function in vivo. This is perhaps unsurprising, as many tissues and organs co...Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments (BUCCAL-PEP)
PartnerEuropean Comission
Oral delivery of peptide macromolecules represents significant challenges for pharmaceutical research, including low bioavailability, dosage control and undesirable food interactions. The intention of the EU-funded BUCCAL-PEP project is to develop a technological platform for oromucosal delivery suitable for a broad range of peptide-ana...Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering (REBORN)
PartnerEuropean Comission
Engineered bone tissue has many advantages over natural bone grafts, including safety and limitless supply. However, current engineering methods cannot generate large vascularised grafts capable of in vivo integration and remodelling. To address this problem, the EU-funded REBORN project proposes to combine biomaterials based on protein...Hybrid living bioengineered hierarchical constructs with self-oxygenating capability (O2CELLS)
PartnerFundação para a Ciência e a Tecnologia
Tissue engineering (TE) has emerged as an alternative solution aiming to provide a surplus of temporary structural supports at the defect site until native tissue is endogenously regenerated and normal function is restored. Although progresses have been made in the last 20 years, it is not yet possible to address all the complexity and (multi)fu...3D cells colonization in marine-derived hydrogels through controlled micro-channels patterning for bone repair (PROMENADE)
PartnerFundação para a Ciência e a Tecnologia
magnetic; 3D cell colonization; hydrogelBioinspired tile-matching to create ultrastructured bone microtissues in a close-to-native fashion (TETRISSUE)
PartnerFundação para a Ciência e a Tecnologia
The driving force behind TETRISSUE is inspired in the fundamentals of the native bone regenerative process and supported by a strong technological character to produce highly vascularized ultrastructured bone replacements. Its innovative character is mainly related with the integration of key elements working in tandem: (1) bioinstructi...Publications
Multi-layer pre-vascularized magnetic cell sheets for bone regeneration
Silva, AS; Santos, LF; Mendes, MC; Mano, JF
2020, BIOMATERIALS, 231.
ISBN:
1878-5905
Complex-shaped magnetic 3D cell-based structures for tissue engineering
Santos, LF; Silva, AS; Mano, JF
2020, ACTA BIOMATERIALIA, 118, 18-31.
ISBN:
1878-7568
Rational design of multistage drug delivery vehicles for pulmonary RNA interference therapy
A. SofiaSilva, Kevin E.Shopsowitz, Santiago Correa, Stephen W.Morton, Erik C.Dreaden, Teresa Casimiro, Ana Aguiar-Ricardo, Paula T.Hammond
2020, International Journal of Pharmaceutics, 591.
Physical immobilization of particles inspired by pollination
Santos, LF; Silva, AS; Correia, CR; Mano, JF
2019, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116, 12, 5405-5410.
Biomaterials for drug delivery patches
Santos, LF; Correia, IJ; Silva, AS; Mano, JF
2018, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 118, 49-66.
Tuneable spheroidal hydrogel particles for cell and drug encapsulation
Bjorge, IM; Costa, AMS; Silva, AS; Vidal, JPO; Norega, JM; Mano, JF
2018, SOFT MATTER, 14, 27, 5622-5627.
Aerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung delivery
A. SofiaSilva, Ana M.Sousa, Renato P.Cabral, Marta C.Silva, Clarinda Costa, Sónia P.Miguel, Vasco D.B.Bonifácio, Teresa Casimiro, Ilídio J.Correia, Ana Aguiar-Ricardo
2017, International Journal of Pharmaceutics, 519, 1-2.
Supercritical CO2-Assisted Spray Drying of Strawberry-Like Gold-Coated Magnetite Nanocomposites in Chitosan Powders for Inhalation
Marta C. Silva, Ana Sofia Silva, Javier Fernandez-Lodeiro, Teresa Casimiro, Carlos Lodeiro and Ana Aguiar-Ricardo
2017, Materials Horizons, 10, 1-2.
Nano‐in‐Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery
Rita B. Restani, A. Sofia Silva, Rita F. Pires, Renato Cabral, Ilídio J. Correia, Teresa Casimiro, Vasco D. B. Bonifácio, Ana Aguiar-Ricardo
2016, Particle & Particle Characterization, 33, 11, 851-858.
Design of experiments approach on the preparation of dry inhaler chitosan composite formulations by supercritical CO2-assisted spray-drying
R.P.Cabral, A.M.L.Sousa, A.S.Silva, A.I.Paninho, M.Temtem, E.Costa, T.Casimiro, A.Aguiar-Ricardo
2016, The Journal of Supercritical Fluids, 116, 26-35.
