Description
The driving force behind TETRISSUE is inspired in the fundamentals of the native bone regenerative process and supported by a strong technological character to produce highly vascularized ultrastructured bone replacements. Its innovative character is mainly related with the integration of key elements working in tandem: (1) bioinstructive microplatforms will guide mesenchymal stem cell (MSCs) chondrogenesis and will originate (2) chondrogenic biotiles as endochondral ossification cartilaginous templates, which will be encapsulated with freely dispersed endothelial and extra MSCs in (3) liquefied capsules, aiming at developing an injectable and in situ strategy upon combination with (4) human-based pre-hydrogels, enriched with specific biomolecules and growth factors that will enable the recruitment of host vessels.This innovative approach should bring bone tissue engineering up to the standard of care in regenerative medicine.”
Coordinator
Syeda Bakht
Coordination
Universidade de Aveiro (UA)
Partners
no
Groups
G4 - Renewable Materials and Circular Economy;
G5 - Biomimetic, Biological and Living Materials;
Outputs
Viscous Microcapsules as Microbioreactors to Study Mesenchymal Stem/Stromal Cells Osteolineage Commitment
Ghasemzadeh-Hasankolaei, M; Miranda, JM; Correia, CR; Mano, JFLIQUIFIED MICROCAPSULES: A VERSTILE PLATFORM TO APPLY HIGH HYDROSTATIC PRESSURE TO HUMAN ADIPOSE-DERIVED MESENCHYMAL STEM CELLS FOR OSTEOGENIC DIFFERENTIATION
Ghasemzadeh-Hasankolaei, M; Pinto, CA; Saraiva, JA; Mano, JFEngineering immunomodulatory hydrogels and cell-laden systems towards bone regeneration
Nadine, S; Correia, CR; Mano, JFLiquefied Microcapsules Compartmentalizing Macrophages and Umbilical Cord-Derived Cells for Bone Tissue Engineering
Nadine, S; Fernandes, I; Patricio, SG; Correia, CR; Mano, JFBioengineered Hierarchical Bonelike Compartmentalized Microconstructs Using Nanogrooved Microdiscs
Bjorge, IM; de Sousa, BM; Patricio, SG; Silva, AS; Nogueira, LP; Santos, LF; Vieira, SI; Haugen, HJ; Correia, CR; Mano, JFHipster microcarriers: exploring geometrical and topographical cues of non-spherical microcarriers in biomedical applications
Bjorge, IM; Correia, CR; Mano, JFSponsors
