Bioinspired tile-matching to create ultrastructured bone microtissues in a close-to-native fashion

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Project Details

Start date
2021-03-28
End date
2024-03-27
%
Acronym
TETRISSUE
Reference
PTDC/BTM-MAT/3201/2020
Funding
Fundação para a Ciência e a Tecnologia
Programme
FCT/PTDC/2020
Budget
249.636 €
Our budget
249.636 €

Team

Description

The driving force behind TETRISSUE is inspired in the fundamentals of the native bone regenerative process and supported by a strong technological character to produce highly vascularized ultrastructured bone replacements. Its innovative character is mainly related with the integration of key elements working in tandem: (1) bioinstructive microplatforms will guide mesenchymal stem cell (MSCs) chondrogenesis and will originate (2) chondrogenic biotiles as endochondral ossification cartilaginous templates, which will be encapsulated with freely dispersed endothelial and extra MSCs in (3) liquefied capsules, aiming at developing an injectable and in situ strategy upon combination with (4) human-based pre-hydrogels, enriched with specific biomolecules and growth factors that will enable the recruitment of host vessels.

This innovative approach should bring bone tissue engineering up to the standard of care in regenerative medicine.”

Coordinator

Sónia Gonçalves Patrício

Coordination

Universidade de Aveiro (UA)

Partners

no

Groups

G5 - Biomimetic, Biological and Living Materials;
G4 - Renewable Materials and Circular Economy;

Outputs

Sponsors

Sponsors
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