Ongoing Supervisions
João António Abreu Pereira
PhD Student
Patrícia Coelho Vigário
Research FellowshipProjects
A bioprinting platform for the rapid, reliable, controlled and quantifiable patterning of cellular aggregatesand microtissues into macroscale regenerative grafts with programmable architectures (m2M)
PartnerEuropean Comission
A fundamental limitation with current approaches aiming to bioprint tissues and organs is an inability to generate constructs with truly biomimetic composition and structure, resulting in the development of engineered tissues that cannot execute their specific function in vivo. This is perhaps unsurprising, as many tissues and organs co...Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments (BUCCAL-PEP)
PartnerEuropean Comission
Oral delivery of peptide macromolecules represents significant challenges for pharmaceutical research, including low bioavailability, dosage control and undesirable food interactions. The intention of the EU-funded BUCCAL-PEP project is to develop a technological platform for oromucosal delivery suitable for a broad range of peptide-ana...Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering (REBORN)
PartnerEuropean Comission
Engineered bone tissue has many advantages over natural bone grafts, including safety and limitless supply. However, current engineering methods cannot generate large vascularised grafts capable of in vivo integration and remodelling. To address this problem, the EU-funded REBORN project proposes to combine biomaterials based on protein...Hybrid living bioengineered hierarchical constructs with self-oxygenating capability (O2CELLS)
PartnerFundação para a Ciência e a Tecnologia
Tissue engineering (TE) has emerged as an alternative solution aiming to provide a surplus of temporary structural supports at the defect site until native tissue is endogenously regenerated and normal function is restored. Although progresses have been made in the last 20 years, it is not yet possible to address all the complexity and (multi)fu...3D cells colonization in marine-derived hydrogels through controlled micro-channels patterning for bone repair (PROMENADE)
PartnerFundação para a Ciência e a Tecnologia
magnetic; 3D cell colonization; hydrogelBioinspired tile-matching to create ultrastructured bone microtissues in a close-to-native fashion (TETRISSUE)
PartnerFundação para a Ciência e a Tecnologia
The driving force behind TETRISSUE is inspired in the fundamentals of the native bone regenerative process and supported by a strong technological character to produce highly vascularized ultrastructured bone replacements. Its innovative character is mainly related with the integration of key elements working in tandem: (1) bioinstructi...Publications
Nanogold POxylation: towards always-on fluorescent lung cancer targeting
A. Sofia Silva, Marta C. Silva, Sónia P. Miguel, Vasco D. B. Bonifácio, Ilídio J. Correia and Ana Aguiar-Ricardo
2016, RSC advances, 6, 33631-33635 .
Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
A. Sofia Silva, Vasco D. B. Bonifácio, Vivek P. Raje, Paula S. Branco, Paulo F. B. Machado, Ilídio J. Correia and Ana Aguiar-Ricardo
2015, RSC Advances, 519, 10733-10738 .
Sustainable strategies for nano-in-micro particle engineering for pulmonary delivery
A. Sofia Silva, Márcia T. Tavares & Ana Aguiar-Ricardo
2014, Journal of Nanoparticle Research volume, 16.
Novel Methodology Based on Biomimetic Superhydrophobic Substrates to Immobilize Cells and Proteins in Hydrogel Spheres for Applications in Bone Regeneration
Ana Catarina Lima, Patrícia Batista, Tiago A.M. Valente, A. Sofia Silva, Ilídio J. Correia, and João F. Mano
2013, Tissue Engineering Part A, 19.
An analysis and validation pipeline for large-scale RNAi-based screens
Michael Plank, Guang Hu, A. Sofia Silva, Shona H. Wood, Emily E. Hesketh, Georges Janssens, André Macedo, João Pedro de Magalhães & George M. Church
2013, Scientific Reports, 33.
Gathering insights on disease etiology from gene expression profiles of healthy tissues
A Sofia Silva, Shona H Wood, Sipko van Dam, Sven Berres, Anne McArdle, João Pedro de Magalhães
2011, Bioinformatics, Volume 27, Issue 23, 3305.
