Projects
Publications
Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation
Daniela S.C. Bispo; Inês Graça; Jennifer H. Haggarty; Aliana Reis; Michael P. McCormick, Sara Bartlome; Mariana B. Oliveira; João F. Mano; Penelope M. Tsimbouri; Matthew J. Dalby; Ana M. Gil
2025, Biomaterials Advances.
Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation
Daniela S.C. Bispo; Inês C.R. Graça; Catarina S.H. Jesus; João E. Rodrigues; Brian J. Goodfellow; Mariana B. Oliveira; João F. Mano; Ana M. Gil
2025, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1870, 7.
Exploring In Vitro Mesenchymal Stem Cell Osteodifferentiation via Vibrational Microspectroscopy: A Comprehensive Review
Daniela S. Bispo; Inês C. R. Graça; João A. Rodrigues; João T. S. Martins; Mariela M. Nolasco; Maria P. M. Marques; Helena I. S. Nogueira; João F. Mano; Mariana B. Oliveira; Paulo J. A. Ribeiro-Claro; Ana M. Gil
2025, Stem Cell Reviews and Reports, 21.
Metabolic markers detect early ostedifferentiation of mesenchymal stem cells from multiple donors
Daniela S. C. Bispo; Inês C. R. Graça; Catarina S. H. Jesus; João E. Rodrigues; Marlene C. Correia; Sabrina Atella; Iola F. Duarte; Brian J. Goodfellow; Mariana B. Oliveira; João F. Mano; Ana M. Gil
2025, Stem Cell Research & Therapy, 16.
Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells
Bispo, DSC; Correia, M; Carneiro, TJ; Martins, AS; Reis, AAN; de Carvalho, ALMB; Marques, MPM; Gil, AM
2023, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 24.
Impact of Sea Warming and 17-a-Ethinylestradiol Exposure on the Lipid Metabolism of Ruditapes philippinarum Clams
Rodrigues, JA; Bispo, DSC; Silva, MG; Araújo, R; Soares, AMVM; Freitas, R; Gil, AM
2023, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 11.
An Intracellular Metabolic Signature as a Potential Donor-Independent Marker of the Osteogenic Differentiation of Adipose Tissue Mesenchymal Stem Cells
Bispo, DSC; Jesus, CSH; Romek, K; Marques, IMC; Oliveira, MB; Mano, JF; Gil, AM
2022, CELLS, 11, 23.
Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation
Bispo, DSC; Michalkova, L; Correia, M; Jesus, CSH; Duarte, IF; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2022, CELLS, 11, 8.
NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells
Bispo, DSC; Jesus, CSH; Correia, M; Ferreira, F; Bonifazio, G; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2022, JOURNAL OF PROTEOME RESEARCH, 21, 3, 654-670.
Metabolomic Applications in Stem Cell Research: a Review
Bispo, DSC; Jesus, CSH; Marques, IMC; Romek, KM; Oliveira, MB; Mano, JF; Gil, AM
2021, STEM CELL REVIEWS AND REPORTS, 17, 6, 2003-2024.
ISBN:
2629-3277
Advancing Chemical-Free Bone Regeneration: The Contribution of Metabolomics to Nanokicking-Driven Osteodifferentiation
Bispo DSC, Tsimbouri PM, JH Haggarty, Graça I, Rodrigues JEA, Oliveira MB, Mano JF, Dalby MJ, Gil AM
2025.
Stem Cell Osteogenic Differentiation Probed by Atomic Force Microscopy-Infrared Nanospectroscopy: Sub-cellular Biochemical Characterization
Martins JTS; Nolasco MM; Rodrigues JEA; Martins CB; Graça I; Carvalho ALMB; Bispo DSC; Oliveira MB; Mano JF; Nogueira HIS; Ribeiro-Claro PJA; Marques MPM; Gil AM
2025.
Uncovering Donor-Dependent Exoproteome Dynamics During MSC Osteogenic Differentiation
Rodrigues JEA; Maurício T; Graça I; Bispo DSC; Oliveira MB; Mano JF; Domingues P; Gil AM
2025.
Exploring MSCs Donor Heterogeneity with Non-Invasive ExoMetabolomics to Find Universal Osteogenic Signatures
Bispo, DSC; Rodrigues, JA; Graça, ICR; Correia, M; Jesus, CSH; Oliveira, MB; Mano, JF; Gil, AM
2024.
Non-invasive detection of universal osteodifferentiation signatures through untargeted NMR Exometabolomics
Bispo, DSC; Rodrigues, JA; Oliveira, MB; Mano, JF; Gil, AM
2024.
Stem Cell Differentiation into Bone Probing Cellular Events by Vibrational Spectroscopy
Marques, MPM; Martins, CB; Carvalho, ALMB; Nolasco, MN; Rodrigues, JA; Bispo, DSC; Nogueira, HIS; Ribeiro-Claro, PJA;, Oliveira, MB; Mano, JF; Gil, AM
2024.
Pioneering Vibrational Spectroscopy to Monitor the Osteodifferentiation of Mesenchymal Stem Cells
Mariela M. Nolasco, João A. Rodrigues, Clara B. Martins, Ana L.M. Batista de Carvalho, Daniela S. C. Bispo, Helena I.S. Nogueira, Paulo J.A. Ribeiro-Claro, Mariana B. Oliveira, João F. Mano, Maria P.M. Marques, Ana M. Gil
2024.
Metabolites Report on Early Stem Cell Osteodifferentiation: New Markers for Effective Bone Regeneration
Daniela S.C. Bispo, João A. Rodrigues, Inês Graça, Catarina S.H. Jesus, Marlene Correia, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
2024.
Unveiling MSCs osteodifferentiation patterns across don ors through non-invasive NMR metabolomics
Daniela S.C. Bispo, Marlene Correia, Joao A. Rodrigues, Mariana B. Oliveira, Joao F. Mano, Ana M. Gil
2024.
Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR exometabolomics
Bispo, DSC; Correia, M; Jesus, CSH; Oliveira, MB; Mano, JF; Gil, AM
2023, TISSUE ENGINEERING PART A, 29, 13-14.
Searching for donor-independent metabolic markers by NMR metabolomics
Gil, AM; Bispo, DSC; Correia, M; Jesus, CSH; Mano, JF; Oliveira, MB
2023, TISSUE ENGINEERING PART A, 29, 13-14.
Unveiling early predictive markers of mesenchymal stem cells osteodifferentiation capacity through NMR metabolomics
Correia MC, Bispo DSC, Jesus CSH, Rodrigues JEA, Oliveira MB, Mano JF, Gil AM
2023.