%
Team
João Borges
Assistant Researcher
João Mano
Vice DirectorDescription
Natural origin polymers from algae and arthropods can be obtained in large scale, and a great effort has been paid to find applications for such high-added value materials. Periodontal disease is frequent in humans and constitutes, together with dental caries, the principal cause of tooth loss in adults. Currently, one of the available treatment strategies for periodontal disease comprises the use of non-resorbable or resorbable membranes as barrier membranes for guided tissue/bone regeneration (GTR/GBR). Such membranes will act as a physical barrier to protect the defect site and to prevent soft tissue to reach the injured area, as well as “guide” the bone regeneration process. Several synthetic and natural membranes are currently being used for GTR/GBR to improve periodontal regeneration but, so far, complete regeneration has not yet been reported. In this concern, BLUETEETH intends to create a pioneering and innovative biocompatible and bioresorbable freestanding (FS) multilayered membrane that would address the limitations of the current ones, in terms of regeneration potential, by promoting an effective GTR/GBR to treat periodontal disease. Such multilayered membrane will have a special design and composition, thus allowing the spatiotemporal control of several parameters, including biocompatibility, biodegradability, mechanical performance, bioactivity and bioadhesion. This project attempts to develop the entire pipeline, bridging the isolation of the marine raw materials up to the final device, with expected improved medical performance and technical characteristics suitable to accelerate market entry.
Coordinator
Coordination
Universidade de Aveiro (UA)
Partners
University of Iceland (UI); Primex ehf (PRIMEX); University of Oslo (UiO)
Outputs
Minimalist Tissue Engineering Approaches Using Low Material-Based Bioengineered Systems
Correia, CR; Bjorge, IM; Nadine, S; Mano, JFBioinstructive Layer-by-Layer-Coated Customizable 3D Printed Perfusable Microchannels Embedded in Photocrosslinkable Hydrogels for Vascular Tissue Engineering
Sousa, CFV; Saraiva, CA; Correia, TR; Pesqueira, T; Patricio, SG; Rial-Hermida, MI; Borges, J; Mano, JFPartial Coated Stem Cells with Bioinspired Silica as New Generation of Cellular Hybrid Materials
Maciel, MM; Correia, TR; Gaspar, VM; Rodrigues, JMM; Choi, IS; Mano, JFIn vitro biological response of human osteoblasts in 3D chitosan sponges with controlled degree of deacetylation and molecular weight
Sukul, M; Sahariah, P; Lauzon, HL; Borges, J; Masson, M; Mano, JF; Haugen, HJ; Reseland, JEInjectable Biomaterials for Dental Tissue Regeneration
Haugen, HJ; Basu, P; Sukul, M; Mano, JF; Reseland, JEPreparation of Well-Dispersed Chitosan/Alginate Hollow Multilayered Microcapsules for Enhanced Cellular Internalization
Ribeiro, C; Borges, J; Costa, AMS; Gaspar, VM; Bermudez, VD; Mano, JFSponsors
Related Projects
Fault-tolerant anticorrosion coatings for magnesium alloys
PTDC/CTM-MET/112831/2009
Core-shell and core-host interactions in functional silicon-nanoparticles
PTDC/FIS/112885/2009
New oxometal compounds with tailored catalytic properties
POCI/QUI/56109/2004