Anticorpos de aves com elevada pureza e estabilidade como biofármacos alternativos no combate à resistência antimicrobiana

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Project Details

Start date
2022-06-01
End date
2023-05-31
Extended date
2023-06-30
%
Acronym
antYmicrob
Reference
CENTRO-01-0145-FEDER-181219
Funding
Industry National
Our budget
149.978 €

Team

Description

O projeto antYmicrob ambiciona aumentar e validar à escala pré-industrial um processo de purificação desenvolvido para anticorpos imunoglobulina Y, e validar o processo com ovos hiperimunes para bactéria Staphylococcus aureus resistente à meticilina (MRSA), assegurando a atividade, estabilidade e não toxicidade dos anticorpos obtidos por ensaios in vitro. Pretende-se também desenvolver a sua formulação para aplicação intravenosa no tratamento de infeções por MRSA, e avaliar a segurança desta formulação através de testes de toxicidade em roedores. Estes ensaios in vivo correspondem a parte dos ensaios pré-clínicos exigidos pelas agências regulamentares, sendo imprescindíveis para a aprovação de um novo fármaco no mercado, assim como para atrair investidores na medida em que se reduz o risco dos biofármacos falharem em fases futuras de ensaios clínicos. Em paralelo, será elaborado um plano de negócios de forma a apresentar a potenciais investidores/licenciadores.

Coordinator

Mara Guadalupe Freire Martins

Coordination

Universidade de Aveiro (UA)

Groups

G5 - Biomimetic, Biological and Living Materials;
G4 - Renewable Materials and Circular Economy;

Outputs

Sponsors

Sponsors
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