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Descrição
Engineered bone tissue has many advantages over natural bone grafts, including safety and limitless supply. However, current engineering methods cannot generate large vascularised grafts capable of in vivo integration and remodelling. To address this problem, the EU-funded REBORN project proposes to combine biomaterials based on proteins obtained from the amniotic membrane and cells from the umbilical cord to develop a 3D device capable of supporting bone tissue formation. Scientists will use hydrogels to provide geometrical, mechanical and topographic cues as well as bioactive soluble factors to drive cell differentiation and recreate the bone marrow niche.
Coordenador
Coordenação
Universidade de Aveiro (UA)
Resultados
Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments
Ghasemzadeh-Hasankolaei, M; Pinto, CA; Jesus, D; Saraiva, JA; Mano, JFBiomaterials of human source for 3D printing strategies
Maia, JR; Sobreiro-Almeida, R; Cleymand, F; Mano, JFViscous Microcapsules as Microbioreactors to Study Mesenchymal Stem/Stromal Cells Osteolineage Commitment
Ghasemzadeh-Hasankolaei, M; Miranda, JM; Correia, CR; Mano, JFBiomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release
Amaral, KR; Silva, AS; Santos, LF; Castanheira, EJ; Mendes, MC; Costa, DCS; Rodrigues, JMM; Marto, J; Mano, JFMagnetic-Based Strategies for Regenerative Medicine and Tissue Engineering
Santos, LF; Silva, AS; Mano, JFDouble-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures
Gonçalves, L; Lavrador, P; Amaral, AJR; Ferreira, LP; Gaspar, VM; Mano, JFA Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture
Zargarzadeh, M; Gomes, MC; Patrício, SG; Custódio, CA; Mano, JFCell Surface Engineering Tools for Programming Living Assemblies
Almeida-Pinto, J; Lagarto, MR; Lavrador, P; Mano, JF; Gaspar, VMSelf-Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom-Up Tissue Engineering
Gomes, MC; Pinho, AR; Custódio, C; Mano, JFFreestanding Magnetic Cell Sheets for Tissue Engineering Applications
Santos, LF; Patrício, SG; Silva, AS; Mano, JFLIQUIFIED MICROCAPSULES: A VERSTILE PLATFORM TO APPLY HIGH HYDROSTATIC PRESSURE TO HUMAN ADIPOSE-DERIVED MESENCHYMAL STEM CELLS FOR OSTEOGENIC DIFFERENTIATION
Ghasemzadeh-Hasankolaei, M; Pinto, CA; Saraiva, JA; Mano, JFEndo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation
Bispo, DSC; Michalkova, L; Correia, M; Jesus, CSH; Duarte, IF; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AMAdvancing Tissue Decellularized Hydrogels for Engineering Human Organoids
Moura, BS; Monteiro, MV; Ferreira, LP; Lavrador, P; Gaspar, VM; Mano, JFEmerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone microenvironment engineering
Jesus, D; Pinho, AR; Gomes, MC; Oliveira, CS; Mano, JFFinanciadores
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