Mariana Braga de Oliveira

Assistant Researcher

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Department

  • Chemistry
  • 29.3.34

Research

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Latest News

Ongoing Supervisions

Ana Filipa Nina e Cunha

PhD Student

Beatriz Guapo Neves

PhD Student

Bruno Daniel Pinto Morais

PhD Student

Deniz Atila

Junior Researcher

Eduarda Mota da Silva

Junior Researcher

Francisca Gonçalves Perfeito

PhD Student

Kamil Ziaja

PhD Student

Marlene Correia

PhD Student

Raquel Maria da Costa Gonçalves

PhD Student

Rita Neves

Research Fellowship

Rosana Martins

PhD Student

Projects

Exploring devitalized MSCs fibres as immunomodulatory devices for wound regeneration through (i) direct promotion of healing or (ii) enabling of allograft transplantation free of systemic immunosuppression (LAZARUS)

CoordinatorOther International
The project aims at exploring MSCs as constituents of off-the-shelf easy-to-handle immunomodulatory biomaterials. The project focuses on using these materials to treat difficult-to-heal wounds, which may be chronic, or have proneness to become chronic if not properly treated.Two treatment approaches will be explored using devitalized MSC aggrega...

Hybrid living bioengineered hierarchical constructs with self-oxygenating capability (O2CELLS)

PartnerFundação para a Ciência e a Tecnologia
Tissue engineering (TE) has emerged as an alternative solution aiming to provide a surplus of temporary structural supports at the defect site until native tissue is endogenously regenerated and normal function is restored. Although progresses have been made in the last 20 years, it is not yet possible to address all the complexity and (multi)fu...

Innovative tools to treat and model complex cancer environments (TheraTools)

PartnerEuropean Comission
Funded by the Marie Skłodowska-Curie Actions programme, the TheraTools project will create a multidisciplinary research and training network to focus on the technological development of scientific tools to study malignant tumours localised beyond a biological barrier, as in the case of brain tumours. The TheraTools consortium will provide high-q...

Merging Sustainable and Digital Chemical Technologies for The Development of Greener-Bydesign Pharmaceuticals (SusPharma)

PartnerEuropean Comission
Safe- and green-by-design are pre-market design approaches whereby the objectives of minimizing the use of hazardous chemicals, reducing greenhouse gas emissions, and fostering the reuse and recycling of materials in a circular economy are built into product design. SUSPHARMA fits the European need for sustainable development in modern industry ...

Metabolite-activated 3D stem cell differentiation into bone (BetterBone)

PartnerFundação para a Ciência e a Tecnologia
Strategies involving mesenchymal stem cell (MSC) osteogenic differentiation have emerged as promising tools in regenerative medicine. These work by either promoting in situ regeneration, or through newly-fabricated tissue grafts, potentially overcoming clinical complications related to more conventional therapies. However, bioengineered bone tiss...

A Metabolomics-guided Bioreactor for Improved Engineered Bone Implants (BioImplant)

PartnerFundação para a Ciência e a Tecnologia

Advancing the Regenerative and Translational Potential of Cellular Fibers (CellFi)

CoordinatorFundação para a Ciência e a Tecnologia
Mesenchymal Stem Cells Scaffold-free Cellular Fibers Regeneration

Cápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)

PartnerFundação para a Ciência e a Tecnologia

Desenvolvimento de hidrogeis de inspiracao marinha multifuncionais e de elevado desempenho para regeneracao de cartilagem, reticulados com ligacoes nao-covalentes e bio-instrutivas deslizantes. (MARGEL)

PartnerFundação para a Ciência e a Tecnologia

Development and testing of multifunctional carriers based on micro- and nanoscale engineering for targeted, controlled, and safe delivery of agrochemicals to crops (Agritarget)

PartnerFundação para a Ciência e a Tecnologia

Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)

PartnerFundação para a Ciência e a Tecnologia

Publications

Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation

Daniela S.C. Bispo; Inês Graça; Jennifer H. Haggarty; Aliana Reis; Michael P. McCormick, Sara Bartlome; Mariana B. Oliveira; João F. Mano; Penelope M. Tsimbouri; Matthew J. Dalby; Ana M. Gil
2025, Biomaterials Advances.

Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation

Daniela S.C. Bispo; Inês C.R. Graça; Catarina S.H. Jesus; João E. Rodrigues; Brian J. Goodfellow; Mariana B. Oliveira; João F. Mano; Ana M. Gil
2025, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1870, 7.

Exploring In Vitro Mesenchymal Stem Cell Osteodifferentiation via Vibrational Microspectroscopy: A Comprehensive Review

Daniela S. Bispo; Inês C. R. Graça; João A. Rodrigues; João T. S. Martins; Mariela M. Nolasco; Maria P. M. Marques; Helena I. S. Nogueira; João F. Mano; Mariana B. Oliveira; Paulo J. A. Ribeiro-Claro; Ana M. Gil
2025, Stem Cell Reviews and Reports, 21.

Metabolic markers detect early ostedifferentiation of mesenchymal stem cells from multiple donors

Daniela S. C. Bispo; Inês C. R. Graça; Catarina S. H. Jesus; João E. Rodrigues; Marlene C. Correia; Sabrina Atella; Iola F. Duarte; Brian J. Goodfellow; Mariana B. Oliveira; João F. Mano; Ana M. Gil
2025, Stem Cell Research & Therapy, 16.

Controlling the diffusion of small molecules from matrices processed by all-aqueous methodologies: towards the development of green pharmaceutical products

Neves, BS; Goncalves, RC; Mano, JF; Oliveira, MB
2024, GREEN CHEMISTRY, 26, 8, 4417-4431.
ISBN: 1463-9270

Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment

Sacramento, MMA; Oliveira, MB; Gomes, JRB; Borges, J; Freedman, BR; Mooney, DJ; Rodrigues, JMM; Mano, JF
2024, ADVANCED HEALTHCARE MATERIALS, 13, 13.
ISBN: 2192-2659

Encapsulated Mesenchymal Stromal Cells as Cyclic Providers of Immunomodulatory Secretomes: A Living on-Demand Delivery System

Sousa, AR; Gonçalves, DC; Neves, BG; Santos-Coquillat, A; Oliveira, MB; Mano, JF
2024, ADVANCED HEALTHCARE MATERIALS, 13, 17.
ISBN: 2192-2659

Shape-Versatile Fixed Cellular Materials for Multiple Target Immunomodulation

Sousa, AR; Cunha, AF; Santos-Coquillat, A; Estrada, BH; Spiller, KL; Barao, M; Rodrigues, AF; Simoes, S; Vilaca, A; Ferreira, L; Oliveira, MB; Mano, JF
2024, ADVANCED MATERIALS, 36, 30.
ISBN: 1521-4095

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Gonçalves, RC; Oliveira, MB; Mano, JF
2024, MATERIALS HORIZONS, 11, 19, 4573-4599.
ISBN: 2051-6355

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All-Aqueous Interfaces

Perfeito, FG; Vilabril, S; Cerqueira, A; Oliveira, MB; Mano, JF
2024, ADVANCED SCIENCE, 11, 45.
ISBN: 2198-3844

Nanofertilizers—synthesis, advantages, and the current status

In Peng Zhang, Iseult Lynch, Jason C. White, Richard D. Handy (Eds.), Nano-Enabled Sustainable and Precision Agriculture
Rodrigues S.M.; Avellan A.; Salvador D.; Rodrigues S.; Miranda M.; Morais B.; Oliveira M.; Mano J.; Lowry G.V.
2023, Nano-enabled Sustainable and Precision Agriculture, 43-77, Elsevier.
ISBN: 978-032391233-4; 978-032399823-9

Advancing Chemical-Free Bone Regeneration: The Contribution of Metabolomics to Nanokicking-Driven Osteodifferentiation

Bispo DSC, Tsimbouri PM, JH Haggarty, Graça I, Rodrigues JEA, Oliveira MB, Mano JF, Dalby MJ, Gil AM
2025.

Stem Cell Osteogenic Differentiation Probed by Atomic Force Microscopy-Infrared Nanospectroscopy: Sub-cellular Biochemical Characterization

Martins JTS; Nolasco MM; Rodrigues JEA; Martins CB; Graça I; Carvalho ALMB; Bispo DSC; Oliveira MB; Mano JF; Nogueira HIS; Ribeiro-Claro PJA; Marques MPM; Gil AM
2025.

Uncovering Donor-Dependent Exoproteome Dynamics During MSC Osteogenic Differentiation

Rodrigues JEA; Maurício T; Graça I; Bispo DSC; Oliveira MB; Mano JF; Domingues P; Gil AM
2025.

Exploring MSCs Donor Heterogeneity with Non-Invasive ExoMetabolomics to Find Universal Osteogenic Signatures

Bispo, DSC; Rodrigues, JA; Graça, ICR; Correia, M; Jesus, CSH; Oliveira, MB; Mano, JF; Gil, AM
2024.

Non-invasive detection of universal osteodifferentiation signatures through untargeted NMR Exometabolomics

Bispo, DSC; Rodrigues, JA; Oliveira, MB; Mano, JF; Gil, AM
2024.

Stem Cell Differentiation into Bone Probing Cellular Events by Vibrational Spectroscopy

Marques, MPM; Martins, CB; Carvalho, ALMB; Nolasco, MN; Rodrigues, JA; Bispo, DSC; Nogueira, HIS; Ribeiro-Claro, PJA;, Oliveira, MB; Mano, JF; Gil, AM
2024.

Pioneering Vibrational Spectroscopy to Monitor the Osteodifferentiation of Mesenchymal Stem Cells

Mariela M. Nolasco, João A. Rodrigues, Clara B. Martins, Ana L.M. Batista de Carvalho, Daniela S. C. Bispo, Helena I.S. Nogueira, Paulo J.A. Ribeiro-Claro, Mariana B. Oliveira, João F. Mano, Maria P.M. Marques, Ana M. Gil
2024.

Metabolites Report on Early Stem Cell Osteodifferentiation: New Markers for Effective Bone Regeneration

Daniela S.C. Bispo, João A. Rodrigues, Inês Graça, Catarina S.H. Jesus, Marlene Correia, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
2024.

Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR exometabolomics

Bispo, DSC; Correia, M; Jesus, CSH; Oliveira, MB; Mano, JF; Gil, AM
2023, TISSUE ENGINEERING PART A, 29, 13-14.

Searching for donor-independent metabolic markers by NMR metabolomics

Gil, AM; Bispo, DSC; Correia, M; Jesus, CSH; Mano, JF; Oliveira, MB
2023, TISSUE ENGINEERING PART A, 29, 13-14.

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