Mariana B. Oliveira

Assistant Researcher

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Department

  • Chemistry
  • 29.3.34

Research

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Mariana B. Oliveira is an Assistant Researcher at the University of Aveiro and a member of CICECO – Aveiro Institute of Materials. She coordinates CICECO’s Health Research Line.

Her research brings together cellular engineering, biomaterials, immunomodulation and regenerative medicine, with particular interest in cell-derived and devitalised cellular materials, and molecular-delivery systems.

She has secured ca. €1.2 million as PI or project coordinator, and participates/has participated in collaborative projects with a combined value exceeding €12 million.

SUPERVISION ACTIVITY (October 2026):

Postdoctoral researchers mentored

  • Deniz Hazal Atila — CellFi and LAZARUS projects
  • Eduarda Mota da Silva — LAZARUS project
  • Ana Alves - SUSPHARMA project
  • Jéssica Barbosa - SUSPHARMA project
  • Ana María Santos Coquillat — CellFi project
  • Adérito Amaral — TranSphera project

Doctoral supervision

Main supervisor

  • Beatriz Guapo Neves — FCT PhD grant; co-supervision with Prof. Roos Masereeuw, Utrecht University.
  • Marlene Cardoso Correia — FCT PhD grant; co-supervision with Prof. Eugénia Carvalho, University of Coimbra.
  • Maria Alexaki — MSCA Doctoral Network TheraTools; co-supervision with Prof. Gianni Ciofani, Italian Institute of Technology, and Prof. João Mano, UA.
  • Kamil Ziaja — MSCA Doctoral Network TheraTools; co-supervision with Prof. Gianni Ciofani and Dr. Attilio Marino, Italian Institute of Technology.
  • Diana Tavares — FCT PhD grant; co-supervision with Dr. João Pedro Silva, University of Porto.
  • Rita Neves — FCT PhD grant in non-academic partnership; co-supervision with Dr. Filipa Gomes and Dr. Ana Sampaio, CENTI.

Co-supervisor

  • Rita Sousa — FCT PhD grant, University of Aveiro; completed.
  • Duarte Félix — FCT PhD grant, University of Beira Interior; completed.
  • Daniela Bispo — SPQ/FCT PhD grant; completed.
  • Ana Filipa Cunha — FCT PhD grant; completed
  • Francisca Perfeito — FCT PhD grant; completed.
  • Raquel Gonçalves — FCT PhD grant.
  • Bruno Morais — FCT PhD grant.
  • Rosana Martins — FCT PhD grant.

Master’s supervision

Main supervisor

  • Simão Santos - MSc in Biomaterials and Nanomedicine (ongoing)/ currently in an international period as a Fulbright fellow at Drexel University, USA.
  • Pedro Silva - MSc in Biotechnology
  • Beatriz Godinho - MSc in Biotechnology
  • Juliana Mendes — MSc in Biomedical Devices; completed.
  • Bárbara Seabra Neves — MSc in Biotechnology; completed.
  • Diana Tavares — MSc in Biotechnology; completed.
  • Leonardo Matias — MSc, co-supervised with Dr. Fátima Macedo, i3S; completed.
  • Diana Lopes — MSc in Biotechnology; completed.
  • Rita Nunes — MSc in Materials and Medical Devices; completed.
  • Mafalda Neto — MSc in Biotechnology; completed.
  • Tânia Salvador — MSc in Biotechnology; completed
  • Raquel Gonçalves — MSc in Biotechnology; completed.
  • Manuel Coelho — MSc in Biotechnology; completed.
  • Diana Gonçalves — MSc in Biotechnology; completed.

Co-supervisor

  • Beatriz Telha — MSc in Biomedical Engineering.
  • Joana Tavares — MSc in Chemical Engineering.
  • Bárbara Baptista — MSc in Biomedical Engineering; completed.
  • Inês Marques — MSc in Biochemistry, completed.

Additional mentoring

Supervision of undergraduate projects in biotechnology, biomedical engineering and biochemistry, project-funded researchers and visiting students, as well as students within the Young Scientist programme at CICECO, Erasmus and Erasmus+ trainees, and a student in the scope of the Gulbenkian Foundation Young Talents (Simão Santos).

Ongoing Supervisions

Beatriz Guapo Neves

PhD Student

Bruno Daniel Pinto Morais

PhD Student

Deniz Atila

Junior Researcher

Diana Fernandes Tavares

PhD Student

Marlene Correia

PhD Student

Rita Neves

Research Fellowship

Rosana Martins

PhD Student

Projects

Exploring devitalized MSCs fibres as immunomodulatory devices for wound regeneration through (i) direct promotion of healing or (ii) enabling of allograft transplantation free of systemic immunosuppression (LAZARUS)

CoordinatorOther International
The project aims at exploring MSCs as constituents of off-the-shelf easy-to-handle immunomodulatory biomaterials. The project focuses on using these materials to treat difficult-to-heal wounds, which may be chronic, or have proneness to become chronic if not properly treated.Two treatment approaches will be explored using devitalized MS...

Innovative tools to treat and model complex cancer environments (TheraTools)

PartnerEuropean Comission
Funded by the Marie Skłodowska-Curie Actions programme, the TheraTools project will create a multidisciplinary research and training network to focus on the technological development of scientific tools to study malignant tumours localised beyond a biological barrier, as in the case of brain tumours. The TheraTools consortium will provide high-q...

A Metabolomics-guided Bioreactor for Improved Engineered Bone Implants (BioImplant)

PartnerFundação para a Ciência e a Tecnologia

Advancing the Regenerative and Translational Potential of Cellular Fibers (CellFi)

CoordinatorFundação para a Ciência e a Tecnologia
Mesenchymal Stem Cells Scaffold-free Cellular Fibers Regeneration

Cápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)

PartnerFundação para a Ciência e a Tecnologia

Desenvolvimento de hidrogeis de inspiracao marinha multifuncionais e de elevado desempenho para regeneracao de cartilagem, reticulados com ligacoes nao-covalentes e bio-instrutivas deslizantes. (MARGEL)

PartnerFundação para a Ciência e a Tecnologia

Development and testing of multifunctional carriers based on micro- and nanoscale engineering for targeted, controlled, and safe delivery of agrochemicals to crops (Agritarget)

PartnerFundação para a Ciência e a Tecnologia

Hybrid living bioengineered hierarchical constructs with self-oxygenating capability (O2CELLS)

PartnerFundação para a Ciência e a Tecnologia
Tissue engineering (TE) has emerged as an alternative solution aiming to provide a surplus of temporary structural supports at the defect site until native tissue is endogenously regenerated and normal function is restored. Although progresses have been made in the last 20 years, it is not yet possible to address all the complexity and (multi)fu...

Merging Sustainable and Digital Chemical Technologies for The Development of Greener-Bydesign Pharmaceuticals (SusPharma)

PartnerEuropean Comission
Safe- and green-by-design are pre-market design approaches whereby the objectives of minimizing the use of hazardous chemicals, reducing greenhouse gas emissions, and fostering the reuse and recycling of materials in a circular economy are built into product design. SUSPHARMA fits the European need for sustainable development in modern industry ...

Metabolite-activated 3D stem cell differentiation into bone (BetterBone)

PartnerFundação para a Ciência e a Tecnologia
Strategies involving mesenchymal stem cell (MSC) osteogenic differentiation have emerged as promising tools in regenerative medicine. These work by either promoting in situ regeneration, or through newly-fabricated tissue grafts, potentially overcoming clinical complications related to more conventional therapies. However, bioengineered ...

Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)

PartnerFundação para a Ciência e a Tecnologia

Publications

Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation

Daniela S.C. Bispo; Inês Graça; Jennifer H. Haggarty; Aliana Reis; Michael P. McCormick, Sara Bartlome; Mariana B. Oliveira; João F. Mano; Penelope M. Tsimbouri; Matthew J. Dalby; Ana M. Gil
2026, Biomaterials Advances.

Cell secretomes used as sole building blocks enable the fabrication of stable hydrogels for biomedical applications

Ana Santos-Coquillat, Beatriz G Neves, Raquel C Gonçalves, Dora CS Costa, João F Mano, Mariana B Oliveira
2026, Matter, 102431.

Controlled Release of Chemically Diverse Small Molecules from Liquid-Core Capsules Assembled in Fully Aqueous Conditions

Neves, Rita C; Neves, Bárbara; Morais, Bruno P.; Gonçalves, Raquel C.; Mano, João F.; Oliveira, Mariana B.; Autor correspondente: Oliveira, Mariana B.
2026, Green Chemistry.

Metabolic markers detect early ostedifferentiation of mesenchymal stem cells from multiple donors

Bispo, DSC; Graça, ICR; Jesus, CSH; Rodrigues, JE; Correia, MC; Atella, S; Duarte, IF; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2025, STEM CELL RESEARCH & THERAPY, 16, 1.

Single-Cell Liquid-Core Microcapsules for Biomedical Applications

Pires-Santos, M; Carreira, M; Morais, BP; Perfeito, FG; Oliveira, MB; Monteiro, CF; Nadine, S; Mano, JF
2025, ADVANCED HEALTHCARE MATERIALS, 14, 10.

Advances in abiotic tissue-based biomaterials: A focus on decellularization and devitalization techniques

Tavares, DF; Mano, JF; Oliveira, MB
2025, MATERIALS TODAY BIO, 32.

Exploring In Vitro Mesenchymal Stem Cell Osteodifferentiation via Vibrational Microspectroscopy: A Review

Bispo, DS; Graça, ICR; Rodrigues, JA; Martins, JTS; Nolasco, MM; Marques, MPM; Nogueira, HIS; Mano, JF; Oliveira, MB; Ribeiro-Claro, PJA; Gil, AM
2025, STEM CELL REVIEWS AND REPORTS, 21, 7, 2043-2065.

Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation

Bispo, DSC; Graça, ICR; Jesus, CSH; Rodrigues, JE; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2025, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1870, 7.

Numerical 3D simulation of the porous microstructures of β-TCP using accessible tools: A Young modulus approach

Macedo, DF; Oliveira, MB; Oliveira, F; Silva, AP
2025, JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 108, 8.

Controlling the diffusion of small molecules from matrices processed by all-aqueous methodologies: towards the development of green pharmaceutical products

Neves, BS; Goncalves, RC; Mano, JF; Oliveira, MB
2024, GREEN CHEMISTRY, 26, 8, 4417-4431.
ISBN: 1463-9270

Nanofertilizers—synthesis, advantages, and the current status

In Peng Zhang, Iseult Lynch, Jason C. White, Richard D. Handy (Eds.), Nano-Enabled Sustainable and Precision Agriculture
Rodrigues S.M.; Avellan A.; Salvador D.; Rodrigues S.; Miranda M.; Morais B.; Oliveira M.; Mano J.; Lowry G.V.
2023, Nano-enabled Sustainable and Precision Agriculture, 43-77, Elsevier.
ISBN: 978-032391233-4; 978-032399823-9

Advancing Chemical-Free Bone Regeneration: The Contribution of Metabolomics to Nanokicking-Driven Osteodifferentiation

Bispo DSC, Tsimbouri PM, JH Haggarty, Graça I, Rodrigues JEA, Oliveira MB, Mano JF, Dalby MJ, Gil AM
2025.

Stem Cell Osteogenic Differentiation Probed by Atomic Force Microscopy-Infrared Nanospectroscopy: Sub-cellular Biochemical Characterization

Martins JTS; Nolasco MM; Rodrigues JEA; Martins CB; Graça I; Carvalho ALMB; Bispo DSC; Oliveira MB; Mano JF; Nogueira HIS; Ribeiro-Claro PJA; Marques MPM; Gil AM
2025.

Uncovering Donor-Dependent Exoproteome Dynamics During MSC Osteogenic Differentiation

Rodrigues JEA; Maurício T; Graça I; Bispo DSC; Oliveira MB; Mano JF; Domingues P; Gil AM
2025.

Exploring MSCs Donor Heterogeneity with Non-Invasive ExoMetabolomics to Find Universal Osteogenic Signatures

Bispo, DSC; Rodrigues, JA; Graça, ICR; Correia, M; Jesus, CSH; Oliveira, MB; Mano, JF; Gil, AM
2024.

Non-invasive detection of universal osteodifferentiation signatures through untargeted NMR Exometabolomics

Bispo, DSC; Rodrigues, JA; Oliveira, MB; Mano, JF; Gil, AM
2024.

Stem Cell Differentiation into Bone Probing Cellular Events by Vibrational Spectroscopy

Marques, MPM; Martins, CB; Carvalho, ALMB; Nolasco, MN; Rodrigues, JA; Bispo, DSC; Nogueira, HIS; Ribeiro-Claro, PJA;, Oliveira, MB; Mano, JF; Gil, AM
2024.

Pioneering Vibrational Spectroscopy to Monitor the Osteodifferentiation of Mesenchymal Stem Cells

Mariela M. Nolasco, João A. Rodrigues, Clara B. Martins, Ana L.M. Batista de Carvalho, Daniela S. C. Bispo, Helena I.S. Nogueira, Paulo J.A. Ribeiro-Claro, Mariana B. Oliveira, João F. Mano, Maria P.M. Marques, Ana M. Gil
2024.

Metabolites Report on Early Stem Cell Osteodifferentiation: New Markers for Effective Bone Regeneration

Daniela S.C. Bispo, João A. Rodrigues, Inês Graça, Catarina S.H. Jesus, Marlene Correia, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
2024.

Unveiling MSCs osteodifferentiation patterns across don ors through non-invasive NMR metabolomics

Daniela S.C. Bispo, Marlene Correia, Joao A. Rodrigues, Mariana B. Oliveira, Joao F. Mano, Ana M. Gil
2024.

Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR exometabolomics

Bispo, DSC; Correia, M; Jesus, CSH; Oliveira, MB; Mano, JF; Gil, AM
2023, TISSUE ENGINEERING PART A, 29, 13-14.

Searching for donor-independent metabolic markers by NMR metabolomics

Gil, AM; Bispo, DSC; Correia, M; Jesus, CSH; Mano, JF; Oliveira, MB
2023, TISSUE ENGINEERING PART A, 29, 13-14.

Unveiling early predictive markers of mesenchymal stem cells osteodifferentiation capacity through NMR metabolomics

Correia MC, Bispo DSC, Jesus CSH, Rodrigues JEA, Oliveira MB, Mano JF, Gil AM
2023.

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