Supervisões em Curso
Projectos
Ativação metabólica da diferenciação 3D de células estaminais em tecido ósseo (BetterBone)
ParticipanteFundação para a Ciência e a Tecnologia
Estratégias que envolvam a diferenciação osteogénica de células estaminais mesenquimais (MSCs) representam ferramentas promissoras na medicina regenerativa, tanto através da promoção da regeneração in situ, como da implanta&...Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments (BUCCAL-PEP)
Coordenador LocalEuropean Comission
Oral delivery of peptide macromolecules represents significant challenges for pharmaceutical research, including low bioavailability, dosage control and undesirable food interactions. The intention of the EU-funded BUCCAL-PEP project is to develop a technological platform for oromucosal delivery suitable for a broad range of peptide-analogue the...Exploração do Potencial Regenerativo e Translacional de Fibras Celulares (CellFi)
ParticipanteFundação para a Ciência e a Tecnologia
Células mesenquimais estaminais Estruturas sem scaffold Fibras Celulares RegeneraçãoHuman Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)
CoordenadorEuropean Comission
Desenvolver scaffolds personalizados com multimateriais altamente bioativos, utilizando tintas com base em lisado de plaquetas e novas técnicas de fabrico aditivo de resolução óptima de impressão Projetar com eficiência compostos biomiméticos altamen...Hybrid living bioengineered hierachical constructs with self-oxygenating capability for bone engineering (O2CELLS)
CoordenadorEuropean Comission
Laboratório Associado CICECO-Instituto de Materiais de Aveiro (LA/P/0006/2020)
ParticipanteFundação para a Ciência e a Tecnologia
PRInted Symbiotic Materials as a dynamic platform for Living Tissues production (PRISM-LT)
Coordenador LocalEuropean Comission
The EU-funded PRISM-LT project will use a hybrid living materials concept to create a flexible platform for living tissue manufacturing. The innovative bio-ink will contain stem cells integrated into a supporting matrix with engineered helper bacteria or yeast cells. The bioprinting process will produce a 3D patterned structure where st...A bioactivated nano-layered hydrogel for dermal regeneration in hard-to-heal ulcers (BioNaNor)
Coordenador LocalOther International
Several strategies have been developed to restore dermal function. These include collagen membranes, decellularized dermis from donors or synthetic graft alternatives. So far, these approaches have been unreliable at best and auto-grafts and transplants (that both create their own problems with donor site morbidity, risk for disease transfer and...Bioengineered autonomous cell-biomaterials devices for generating humanised micro- tissues for regenerative medicine (ATLAS)
CoordenadorEuropean Comission
New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine an...Biopolímeros de origem marinha como blocos de construção inovadores do mar para o desenvolvimento de membranas bioreabsorvíveis multicamada para regeneração guiada de osso (BLUETEETH)
CoordenadorFundação para a Ciência e a Tecnologia
Natural origin polymers from algae and arthropods can be obtained in large scale, and a great effort has been paid to find applications for such high-added value materials. Periodontal disease is frequent in humans and constitutes, together with dental caries, the principal cause of tooth loss in adults. Currently, one of the available treatment...Biorrefinaria de microalgas Coccolithophore: uma abordagem para biomateriais sustentaveis (Coccolitho4BioMat)
ParticipanteFundação para a Ciência e a Tecnologia
Cápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)
ParticipanteFundação para a Ciência e a Tecnologia
Colonizacao 3D de celulas em hidrogeis de origem marinha atraves de padronizacao por microcanais para regeneracao ossea (PROMENADE)
ParticipanteFundação para a Ciência e a Tecnologia
magnetic; 3D cell colonization; hydrogelDesenvolvimento de termometria sem fios a 4D tendo como alvo a ablação de tumores (PTDC/NAN-MAT/3901/2020)
ParticipanteFundação para a Ciência e a Tecnologia
Thermografia Nanopartículas Magnéticas Hipertermia induzida BioimpressãoDesenvolvimento de uma membrana periodontal multicamada composta por blocos inovativos a base de polimeros de origem marinha e enzima para regeneracao guiada de osso que possui mineralizacao enzimatica controlada. (MIMETIc)
ParticipanteFundação para a Ciência e a Tecnologia
Dispositivos Supramoleculares Auto-Regulados baseados na Complementaridade dos Pares de Base do ADN: Uma Tecnologia Biomimética e com Reconheciemnto Molecular para Isolar Células Específicas para Aplicações Biomédicas (SUPRASORT)
ParticipanteFundação para a Ciência e a Tecnologia
Enabling precision chemical methodologies applied to natural -based systems for the development of multifunctional biomedical devices (CHEM2NATURE)
Coordenador LocalEuropean Comission
CHEM2NATURE addresses current limitations of UMINHO in the Chemistry field regarding its scientific know-how and partnerships with world-leading institutions. UMINHO seeks to improve the multifunctionality of natural-origin polymers, often with limited bioactivity and stimuli-responsiveness, and increase the performance of cell-based therapies. ...European Network of Bioadhesion Expertise: Fundamental Knowledge to Inspire Advanced Bonding Technologies (COST Action CA15216)
Coordenador LocalEuropean Comission
Many organisms, ranging from bacteria and fungi to those much larger animals and plants use chemical and mechanical means to attach permanently or temporarily to surfaces. Some bioadhesives have advantages over synthetic counterparts in terms of their ability to function over a wide temperature range, in wet or dry environments, and to form stab...Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models (AMNIOGEL)
CoordenadorEuropean Comission
Hidralazina - uma nova abordagem terapêutica no Carcinoma da próstata resistente à castração (HyTherCaP)
Coordenador LocalFundação para a Ciência e a Tecnologia
O carcinoma da próstata (CaP) é uma das neoplasias malignas mais prevalentes no mundo e uma das principais causas de morbilidade e mortalidade oncológica. Em Portugal é o cancro mais incidente e a 3ª causa de morte por cancro no homem (1, 2). Apesar da maioria dos CaPs diagnosticados serem cli...Hidrogéis de Lisados de Plaquetas para Regeneração do Miocárdio (BEAT)
ParticipanteFundação para a Ciência e a Tecnologia
Human based bioinks to engineer physiologically relevant tissues (HumanINK)
CoordenadorEuropean Comission
Bioprinting techniques, which integrate 3D printing with tissue engineering by using living cells encapsulated in natural or synthetic biomaterials as bioinks, are paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds' new frontiers in medicine, pharmaceutical, and food industries.Human...Metodologias eficientes para a conjugação de polissacarídeos naturais com péptidos para obtenção de membranas multifuncionais para regeneração periodontal. (COP2P)
ParticipanteFundação para a Ciência e a Tecnologia
Mosaicos bioinspirados para o desenvolvimento de microtecidos ósseos ultra-estruturados; (TETRISSUE)
ParticipanteFundação para a Ciência e a Tecnologia
ossificação endocondral engenharia de tecidos modular mecanobiologia co-culturas 3DNovel 3D platforms to engineer bone microtissues for in vitro disease models; (Microbone)
CoordenadorEuropean Comission
Osteosarcoma is a rare but devastating bone tumour that mainly affects children, adolescents and elderly. This type of tumour is very resistant to therapy, being thus urgent to find new effective treatments. In vitro tumour models can recapitulate many aspects of the natural tumour environment, and could be used to improve the predictive value o...Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)
ParticipanteFundação para a Ciência e a Tecnologia
Sondas neuronais fotónicas integradas para computação neuromórfica (PHEASANT)
ParticipanteFundação para a Ciência e a Tecnologia
Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus:a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche (ELASTISLET)
Coordenador LocalEuropean Comission
ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them ...Publicações
Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment
Margarida M. A. Sacramento, Mariana B. Oliveira, José R.B. Gomes, João Borges, Benjamin R. Freedman, David J. Mooney, João M.M. Rodrigues, João F. Mano
2024, Advanced Healthcare Materials.
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In-Bath 3D Printing of Anisotropic Shape-Memory Cryogels Functionalized with Bone-Bioactive Nanoparticles
Edgar J. Castanheira, Luís P. G. Monteiro, Vítor M. Gaspar, Tiago R. Correia, João M. M. Rodrigues, João F. Mano
2024, ACS Applied Materials and Interfaces, 16, 15.
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Human Chorionic Membrane-derived Tunable Hydrogels for Vascular Tissue Engineering Strategies
Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, and Catarina A. Custódio
2024, Advanced Healthcare Materials, 2401510.
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A Supramolecular Injectable Methacryloyl Chitosan-tricine-based Hydrogel with 3D printing potential for tissue engineering applications
Pedro M.S. Ouro, Dora C.S. Costa, Adérito J.R. Amaral, João F. Mano
2023, Macromolecular Bioscience.
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Bioactive Self-Regulated Liquified Microcompartments to Bioengineer Bone-Like Microtissues
Ana R. Pinho; Gomes, Maria C. Gomes; Dora C. S. Costa; Mano, João F. Mano
2023, Small.
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In situ generated hemostatic adhesives: From mechanisms of action to recent advances and applications
Luís P.G. Monteiro, João M.M. Rodrigues, João F. Mano
2023, Biomaterials Advances, 155.
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Bioinspired Oxidation-Resistant Catechol-like Sliding Ring Polyrotaxane Hydrogels
Rial-Hermida, MI; Costa, DCS; Jiang, L; Rodrigues, JMM; Ito, K; Mano, JF
2023, GELS, 9, 2.
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Organoids of the male reproductive system: Challenges, opportunities, and their potential use in fertility research
Patricio, D; Santiago, J; Mano, JF; Fardilha, M
2023, WIRES MECHANISMS OF DISEASE, 15, 2.
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Mechanical Characterization of 3D-Printed Patterned Membranes for Cardiac Tissue Engineering: An Experimental and Numerical Study
Poerio, A; Guibert, B; Leroux, MM; Mano, JF; Cleymand, F; Jehl, JP
2023, BIOMEDICINES, 11, 3.
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Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research
Ferreira, T; Gama, A; Seixas, F; Faustino-Rocha, AI; Lopes, C; Gaspar, VM; Mano, JF; Medeiros, R; Oliveira, PA
2023, VETERINARY SCIENCES, 10, 6.
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Nanofertilizers—synthesis, advantages, and the current status
In Peng Zhang, Iseult Lynch, Jason C. White, Richard D. Handy (Eds.), Nano-Enabled Sustainable and Precision Agriculture
Rodrigues S.M.; Avellan A.; Salvador D.; Rodrigues S.; Miranda M.; Morais B.; Oliveira M.; Mano J.; Lowry G.V.
2023, Nano-enabled Sustainable and Precision Agriculture, 43-77, Elsevier.
ISBN:
978-032391233-4; 978-032399823-9
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Animal Protein-based Soft Materials for Tissue Engineering Applications
In Helena S. Azevedo, João F. Mano, João Borges (Eds.), Soft Matter for Biomedical Applications
C. A. Custódio, S. C. Santos, C. F. Monteiro, I. A. Deus, M. C. Gomes, J. F. Mano
2021, Royal Society of Chemistry.
ISBN:
978-1-78801-757-2
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Extending the Functionality of Marine-origin Polysaccharides Through Chemical Modification for Biomedical Applications
In Helena S. Azevedo, João F. Mano, João Borges (Eds.), Soft Matter for Biomedical Applications
João M. M. Rodrigues, Edgar J. Castanheira, Dora C. S. Costa, Djenisa H. A. Rocha, João Borges and João F. Mano
2021, 180-204, Royal Society of Chemistry (RSC).
ISBN:
978-1-78801-757-2
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Cell-based soft biomaterials
Soft Matter for Biomaterial Applications
A. Sofia Silva, Lúcia F. Santos, Mariana B. Oliveira and João F. Mano
2021.
ISBN:
978-1-78801-757-2
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Smart Instructive Polymer Substrates for Tissue Engineering
In Maria Rosa Aguilar, Julio San Román (Eds.), Smart Polymers and Their Applications
Catarina A.Custódio, Aránzazudel Campo, Rui L.Reis, João F.Mano
2019, 411-438, Woodhead Publishing .
ISBN:
978-0-08-102416-4
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