funding type |
European Comission |
programme |
H2020-FETOPEN-1-2016-2017 |
acronym/
reference |
NanoTBTech |
alternative reference |
801305 |
research group(s) |
1 - inorganic functional nanomaterials and organic-inorganic hybrids; |
department |
Physics (DF) |
execution dates |
2018-09-01 - 2021-08-31 (
36 Months )
|
project extension date |
2022-02-28 (
6 Extra months )
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abstract/
keywords |
Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 ?m is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.
The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.
In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas. |
coordinator
/local pi |
Luís António Ferreira Martins Dias Carlos |
ciceco status |
Coordinator |
proponent institution |
Universidade de Aveiro (UA) |
partner institution(s) |
Fundacion Para La Investigacion Biomedica Del Hospital Universitario Ramon Y Cajal (Spain); Centre National De La Recherche Scientifique Cnrs (France); Institut Za Nuklearne Nauke Vinca (Serbia); Agencia Estatal Consejo Superior De Investigaciones Cientificas; (Spain); Instytut Niskich Temperatur I Badan Strukturalnych Im. Wlodzimierza Trzebiatowskiego Polskiej Akademii Nauk (Poland); Universiteit Utrecht (Netherlands); Nanoimmunotech Sl (Spain); Biospace Lab (France)
|
international partner(s) |
yes |
total budget |
2.999.483€
|
ciceco budget |
508.060€
|
project code |
3.89.265 |
link |
https://cordis.europa.eu/project/rcn/216329_en.html
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Ga-modified YAG:Pr3+ dual-mode tunable luminescence thermometersBolek, P; Zeler, J; Brites, CDS; Trojan-Piegza, J; Carlos, LD; Zych, E 2021, CHEMICAL ENGINEERING JOURNAL, 421,
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Going Above and Beyond: A Tenfold Gain in the Performance of Luminescence Thermometers Joining Multiparametric Sensing and Multiple RegressionMaturi, FE; Brites, CDS; Ximendes, EC; Mills, C; Olsen, B; Jaque, D; Ribeiro, SJL; Carlos, LD 2021, LASER & PHOTONICS REVIEWS, 15, 11,
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Thermal enhancement of upconversion emission in nanocrystals: a comprehensive summaryShi, R; Martinez, ED; Brites, CDS; Carlos, LD 2021, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 23, 1,
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Spectral and thermometric properties altering through crystal field strength modification and host material composition in luminescence thermometers based on Fe3+ doped AB(2)O(4) type nanocrystals (A = Mg, Ca; B = Al, Ga)Kniec, K; Piotrowski, W; Ledwa, K; Carlos, LD; Marciniak, L 2021, JOURNAL OF MATERIALS CHEMISTRY C, 9, 2, 517-527.
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Controlling the thermal switching in upconverting nanoparticles through surface chemistryMartinez, ED; Garcia-Flores, AF; Carneiro, AN; Brites, CDS; Carlos, LD; Urbano, RR; Rettori, C 2021, NANOSCALE, 13, 38, 16267-16276.
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From quencher to potent activator - Multimodal luminescence thermometry with Fe3+ in the oxides MAl4O7 (M = Ca, Sr, Ba)Kniec, K; Piotrowski, W; Ledwa, K; Suta, M; Carlos, LD; Marciniak, L 2021, JOURNAL OF MATERIALS CHEMISTRY C, 9, 19, 6268-6276.
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Efficient Brownian oscillators and nanoheaters based on gallium-doped epsilon-Fe2O3Gu, YY; Silva, NJO; Yoshikiyo, M; Namai, A; Pinol, R; Maurin-Pasturel, G; Cui, YW; Ohkoshi, SI; Millan, A; Martinez, A 2021, CHEMICAL COMMUNICATIONS, 57, 18, 2285-2288.
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Standardizing luminescence nanothermometry for biomedical applicationsBednarkiewicz, A; Marciniak, L; Carlos, LD; Jaque, D 2020, NANOSCALE, 12, 27, 14405-14421.
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[Ga83+Sm23+, Ga83+Tb23+] Metallacrowns are Highly Promising Ratiometric Luminescent Molecular Nanothermometers Operating at Physiologically Relevant TemperaturesSalerno, EV; Zeler, J; Eliseeva, SV; Hernandez-Rodriguez, MA; Neto, ANC; Petoud, S; Pecoraro, VL; Carlos, LD 2020, CHEMISTRY-A EUROPEAN JOURNAL, 26, 61, 13792-13796.
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Real-Time Intracellular Temperature Imaging Using Lanthanide Bearing Polymeric MicellesPinol, R; Zeler, J; Brites, CDS; Gu, YY; Tellez, P; Neto, ANC; da Silva, TE; Moreno-Loshuertos, R; Fernandez-Silva, P; Gallego, AI; Martinez-Lostao, L; Martinez, A; Carlos, LD; Millan, A 2020, NANO LETTERS, 20, 9, 6466-6472.
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Magnetic hyperthermia with epsilon-Fe(2)O(3)nanoparticlesGu, YY; Yoshikiyo, M; Namai, A; Bonvin, D; Martinez, A; Pinol, R; Tellez, P; Silva, NJO; Ahrentorp, F; Johansson, C; Marco-Brualla, J; Moreno-Loshuertos, R; Fernandez-Silva, P; Cui, YW; Ohkoshi, S; Millan, A 2020, RSC ADVANCES, 10, 48, 28786-28797.
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Decoding a Percolation Phase Transition of Water at similar to 330 K with a Nanoparticle RulerBrites, CDS; Zhuang, BL; Debasu, ML; Ding, D; Qin, X; Maturi, FE; Lim, WWY; Soh, D; Rocha, J; Yi, ZG; Liu, XG; Carlos, LD 2020, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 11, 16, 6704-6711.
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Ag2S Nanoheaters with Multiparameter Sensing for Reliable Thermal Feedback during In Vivo Tumor TherapyShen, YL; Santos, HDA; Ximendes, EC; Lifante, J; Sanz-Portilla, A; Monge, L; Fernandez, N; Coria, IC; Jacinto, C; Brites, CDS; Carlos, LD; Benayas, A; Iglesias-de la Cruz, MC; Jaque, D 2020, ADVANCED FUNCTIONAL MATERIALS, 30, 49,
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Lanthanide-Based Thermometers: At the Cutting-Edge of Luminescence ThermometryBrites, CDS; Balabhadra, S; Carlos, LD 2019, ADVANCED OPTICAL MATERIALS, 7, 5,
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Electrochromic Switch Devices Mixing Small- and Large-Sized Upconverting NanocrystalsMartinez, ED; Brites, CDS; Carlos, LD; Garcia-Flores, AF; Urbano, RR; Rettori, C 2019, ADVANCED FUNCTIONAL MATERIALS, 29, 8,
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Perspectives for Ag2S NIR-II nanoparticles in biomedicine: from imaging to multifunctionalityShen, YL; Lifante, J; Ximendes, E; Santos, HDA; Ruiz, D; Juarez, BH; Gutierrez, IZ; Vera, VA; Retama, JR; Rodriguez, EM; Ortgies, DH; Jaque, D; Benayas, A; del Rosal, B 2019, NANOSCALE, 11, 41, 19251-19264.
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